Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression.
Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression.
复制标题
溶血磷脂酸的产生和作用：乳腺癌发生和进展的关键新参与者。
DOI：
10.1038/sj.bjc.6605588
复制
发表时间：
2010-03-16
影响因子：
8.8
通讯作者：
中科院分区：
文献类型：
--
作者：
溶血磷脂酸 (LPA) 是一种有效的脂质介质，作用于一系列特定的 G 蛋白偶联受体，从而产生多种生物作用。溶血磷脂酸诱导细胞增殖、存活和迁移，这是肿瘤形成和转移所必需的。这种生物活性脂质由胞外酶溶血磷脂酶 D 或自分泌运动因子 (ATX) 产生，早期称为自分泌运动因子。 ATX-LPA 信号轴已成为多种癌症的重要参与者。事实上，ATX 和 LPA 受体的异常表达发生在乳腺癌的发生和进展过程中。重要的是，转基因小鼠乳腺中 ATX 或 LPA 受体的表达足以诱导高频率的侵袭性和转移性乳腺癌的发生。现在研究的重点转向了解 ATX 和 LPA 促进乳腺肿瘤发生和转移的机制。针对 ATX-LPA 信号轴进行药物开发可能会进一步改善乳腺癌患者的预后。
Lysophosphatidic acid (LPA) is a potent lipid mediator that acts on a series of specific G protein-coupled receptors, leading to diverse biological actions. Lysophosphatidic acid induces cell proliferation, survival and migration, which are critically required for tumour formation and metastasis. This bioactive lipid is produced by the ectoenzyme lysophospholipase D or autotaxin (ATX), earlier known as an autocrine motility factor. The ATX–LPA signalling axis has emerged as an important player in many types of cancer. Indeed, aberrant expression of ATX and LPA receptors occurs during the development and progression of breast cancer. Importantly, expression of either ATX or LPA receptors in the mammary gland of transgenic mice is sufficient to induce the development of a high frequency of invasive and metastatic mammary cancers. The focus of research now turns to understanding the mechanisms by which ATX and LPA promote mammary tumourigenesis and metastasis. Targeting the ATX–LPA signalling axis for drug development may further improve outcomes in patients with breast cancer.
登录
查看更多内容
影响因子：
254.7
作者：
Jemal, Ahmedin;Siegel, Rebecca;Thun, Michael J.
通讯作者：
Thun, Michael J.
影响因子：
29.4
作者：
Lin S;Wang D;Iyer S;Ghaleb AM;Shim H;Yang VW;Chun J;Yun CC
通讯作者：
Yun CC
影响因子：
4.8
作者：
Pamuklar, Zehra;Federico, Lorenzo;Smyth, Susan S.
通讯作者：
Smyth, Susan S.
DOI：
10.1073/pnas.0903392106
发表时间：
2009-05-19
影响因子：
11.1
作者：
Caldas-Lopes, Eloisi;Cerchietti, Leandro;Chiosis, Gabriela
通讯作者：
Chiosis, Gabriela
DOI：
10.1186/bcr2345
发表时间：
2009
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Das Roy L;Pathangey LB;Tinder TL;Schettini JL;Gruber HE;Mukherjee P
通讯作者：
Mukherjee P