Does immune recognition of SARS-CoV2 epitopes vary between different ethnic groups?
Does immune recognition of SARS-CoV2 epitopes vary between different ethnic groups?
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DOI：
10.1016/j.virusres.2021.198579
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发表时间：
2021-11
期刊：
影响因子：
5
通讯作者：
Mande SS
中科院分区：
文献类型：
--
作者：
Bose T;Pant N;Pinna NK;Bhar S;Dutta A;Mande SS
SARS-CoV2介导的Covid-19大流行对人类造成了前所未有的影响。虽然大量的研究工作集中在了解病毒感染的机制和开发疫苗/疗法上，但影响SARS-CoV2感染易感性和Covid-19表现的因素仍未被探索。鉴于人类白细胞抗原（HLA）系统在不同种族人群中存在差异，这可能会影响对病毒的识别，进而影响对Covid-19的易感性。为了理解这一点，我们使用生物信息学工具探测了所有可能引起人类t细胞反应的SARS-CoV2肽。我们还试图通过研究HLA等位基因在不同人群中的分布及其同源表位的份额来回答这些潜在表位在不同种族之间是否具有相同的免疫原性这一有趣的问题。结果表明，不同民族对SARS-CoV2表位的免疫识别潜力存在差异。南亚人可能识别更多的cd8特异性表位，而欧洲人可能识别更多的cd4特异性表位。我们还假设并提供了线索，即SARS-CoV2的新突变不太可能改变所研究种族人群中t细胞介导的免疫原性反应。本文提出的工作有望加强我们对大流行的理解，通过提供对种族人群对病毒的差异免疫反应的见解，以及通过评估约40,000个病毒基因组来测量SARS-CoV2突变对潜在基于表位的疫苗有效性的可能影响。
The SARS-CoV2 mediated Covid-19 pandemic has impacted humankind at an unprecedented scale. While substantial research efforts have focused towards understanding the mechanisms of viral infection and developing vaccines/ therapeutics, factors affecting the susceptibility to SARS-CoV2 infection and manifestation of Covid-19 remain less explored. Given that the Human Leukocyte Antigen (HLA) system is known to vary among ethnic populations, it is likely to affect the recognition of the virus, and in turn, the susceptibility to Covid-19. To understand this, we used bioinformatic tools to probe all SARS-CoV2 peptides which could elicit T-cell response in humans. We also tried to answer the intriguing question of whether these potential epitopes were equally immunogenic across ethnicities, by studying the distribution of HLA alleles among different populations and their share of cognate epitopes. Results indicate that the immune recognition potential of SARS-CoV2 epitopes tend to vary between different ethnic groups. While the South Asians are likely to recognize higher number of CD8-specific epitopes, Europeans are likely to identify higher number of CD4-specific epitopes. We also hypothesize and provide clues that the newer mutations in SARS-CoV2 are unlikely to alter the T-cell mediated immunogenic responses among the studied ethnic populations. The work presented herein is expected to bolster our understanding of the pandemic, by providing insights into differential immunological response of ethnic populations to the virus as well as by gaging the possible effects of mutations in SARS-CoV2 on efficacy of potential epitope-based vaccines through evaluating ∼40,000 viral genomes.
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