Lower Bmi-1 Expression May Predict Longer Survival of Colon Cancer Patients
Lower Bmi-1 Expression May Predict Longer Survival of Colon Cancer Patients
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较低的 Bmi-1 表达可预测结肠癌患者的较长生存期
DOI：
10.1159/000452510
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发表时间：
2016-11
期刊：
影响因子：
--
通讯作者：
Changping Wu
中科院分区：
文献类型：
--
作者：
Xiaodong Li;Xiao Zheng;Bin Xu;Dachuan Zhang;Yun Xu;Quanqin Xie;Wenwei Hu;huojun Zheng;Yingjie Shao;Jun Wu;Mei Ji;Jingting Jiang;Changping Wu
背景：本研究旨在探讨Bmi-1在结肠癌中的表达及其临床意义。患者与方法：采用免疫组化法检测乳腺癌组织及相应正常组织中Bmi-1的表达。分析Bmi-1表达与临床病理特征及总生存期（OS）的关系。结果如下：CC组织和相应组织中Bmi-1的中位H评分分别为80.0（0-270）和5.0（0-90），差异无统计学意义（Z=-13.7，P<0.001）。Bmi-1在CC组织中的表达与任何特征均无统计学相关性。Bmi-1高表达或低表达的CC患者的中位OS时间分别为53.7个月和44.9个月，差异无统计学意义（P = 0.123）。Bmi-1低表达患者的生存率高于高表达患者，但差异无统计学意义。结论：膀胱癌组织中Bmi-1的表达明显高于相应的正常组织。虽然可能存在生存率提高的趋势，但这在统计学上并不显著。
Background: This study aimed to investigate the Bmi-1 expression and the clinical significance in colon cancer (CC). Patients and Methods: Bmi-1 expression in tumor tissue and the corresponding normal tissue was detected using immunohistological staining. The correlations between Bmi-1 expression and clinicopathological characteristics and the overall survival (OS) time were analyzed. Results: The median H-scores of Bmi-1 in CC tissues and the corresponding tissues were 80.0 (0-270) and 5.0 (0-90), with no statistically significant difference (Z=-13.7, P<0.001). Bmi-1 expression in CC tissues was not statistically correlated with any characteristics. The median OS times for CC patients with high or low Bmi-1 expression were 53.7 months and 44.9 months, respectively, with no statistically significant difference (P = 0.123). The survival rates of patients with low Bmi-1 expression were higher than those of patients with high Bmi-1 expression but the differences were not statistically significant. Conclusion: Bmi-1 expression in CC tissue is significantly higher than that in corresponding normal tissue. While there may be a trend towards improved survival, this is not statistically significant.
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DOI：
10.1016/b978-1-4160-3251-9.50008-x
发表时间：
2019-10
期刊：
The Lancet
影响因子：
--
作者：
E. Dekker;P. Tanis;J. Vleugels;P. Kasi;M. Wallace
通讯作者：
E. Dekker;P. Tanis;J. Vleugels;P. Kasi;M. Wallace
影响因子：
168.9
作者：
Cunningham, David;Atkin, Wendy;Starling, Naureen
通讯作者：
Starling, Naureen
影响因子：
168.9
作者：
Midgley, R;Kerr, D
通讯作者：
Kerr, D
DOI：
10.1007/s00432-007-0316-8
发表时间：
2008-05-01
影响因子：
3.6
作者：
Wang, Hui;Pan, Ke;Xia, Jian-chuan
通讯作者：
Xia, Jian-chuan
MicroRNA-218 通过下调 BMI1 多梳环指癌基因抑制结肠癌细胞周期进程并促进细胞凋亡
影响因子：
5.7
作者：
He, Xinqi;Dong, Yujuan;Yu, Jun
通讯作者：
Yu, Jun