A role for chemokine signaling in neural crest cell migration and craniofacial development.
A role for chemokine signaling in neural crest cell migration and craniofacial development.
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DOI：
10.1016/j.ydbio.2009.06.031
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发表时间：
2009-09-01
影响因子：
2.7
通讯作者：
Artinger, Kristin Bruk
中科院分区：
文献类型：
--
作者：
Killian, Eugenia C. Olesnicky;Birkholz, Denise A.;Artinger, Kristin Bruk
神经嵴细胞（NCCs）是一种独特的多能细胞群，它们沿着胚胎内特定的路径迁移，并产生许多不同类型的细胞，包括色素细胞、颅面软骨和周围神经系统（PNS）。神经嵴细胞的异常迁移会导致多种先天性出生缺陷，包括颅面异常。趋化因子Sdf1及其受体Cxcr4和Cxcr7已被确定为多种组织中细胞迁移调节的关键成分。在此，我们描述了斑马鱼趋化因子受体Cxcr4a在颅神经嵴细胞（CNCCs）发育和迁移中的一种新作用。我们发现，Cxcr4a缺失（而非Cxcr7b缺失）会导致颅神经嵴细胞异常迁移、神经颅缺陷以及颅神经节畸形。此外，Sdf1b或Cxcr4a的过表达会导致颅神经嵴细胞异常迁移，并产生异位颅面软骨。我们提出一个模型，即来自咽弓内胚层和视柄的Sdf1b信号传导至表达Cxcr4a的颅神经嵴细胞，对于颅神经嵴细胞正确聚集形成咽弓以及随后神经嵴衍生组织的模式形成和形态发生都非常重要。
Neural crest cells (NCCs) are a unique population of multipotent cells that migrate along defined pathways throughout the embryo and give rise to many diverse cell types including pigment cells, craniofacial cartilage and the peripheral nervous system (PNS). Aberrant migration of NCCs results in a wide variety of congenital birth defects including craniofacial abnormalities. The chemokine Sdf1 and its receptors, Cxcr4 and Cxcr7, have been identified as key components in the regulation of cell migration in a variety of tissues. Here we describe a novel role for the zebrafish chemokine receptor Cxcr4a in the development and migration of cranial NCCs (CNCCs). We find that loss of Cxcr4a, but not Cxcr7b results in aberrant CNCC migration, defects in the neurocranium, as well as cranial ganglia dismorphogenesis. Moreover, overexpression of either Sdf1b or Cxcr4a causes aberrant CNCC migration and results in ectopic craniofacial cartilages. We propose a model in which Sdf1b signaling from the pharyngeal arch endoderm and optic stalk to Cxcr4a expressing CNCCs is important for both the proper condensation of the CNCCs into pharyngeal arches and the subsequent patterning and morphogenesis of the neural crest derived tissues.
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影响因子：
--
作者：
Chen, J N;van Bebber, F;Goldstein, A M;Serluca, F C;Jackson, D;Childs, S;Serbedzija, G;Warren, K S;Mably, J D;Lindahl, P;Mayer, A;Haffter, P;Fishman, M C
通讯作者：
Fishman, M C
影响因子：
4.6
作者：
Holzschuh, J;Wada, N;Schillili, TF
通讯作者：
Schillili, TF
影响因子：
--
作者：
Dambly-Chaudière C;Cubedo N;Ghysen A
通讯作者：
Ghysen A
影响因子：
2.5
作者：
KIMMEL, CB;BALLARD, WW;SCHILLING, TF
通讯作者：
SCHILLING, TF
影响因子：
4
作者：
Dumstrei, K;Mennecke, R;Raz, E
通讯作者：
Raz, E