Genome-wide analyses of long noncoding RNA expression profiles in lung adenocarcinoma.
Genome-wide analyses of long noncoding RNA expression profiles in lung adenocarcinoma.
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肺腺癌中长非编码 RNA 表达谱的全基因组分析
DOI：
10.1038/s41598-017-15712-y
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发表时间：
2017-11-10
影响因子：
4.6
通讯作者：
Duan C
中科院分区：
文献类型：
--
作者：
Peng Z;Wang J;Shan B;Yuan F;Li B;Dong Y;Peng W;Shi W;Cheng Y;Gao Y;Zhang C;Duan C
LncRNAs have emerged as a novel class of critical regulators of cancer. We aimed to construct a landscape of lncRNAs and their potential target genes in lung adenocarcinoma. Genome-wide expression of lncRNAs and mRNAs was determined using microarray. qRT-PCR was performed to validate the expression of the selected lncRNAs in a cohort of 42 tumor tissues and adjacent normal tissues. R and Bioconductor were used for data analysis. A total of 3045 lncRNAs were differentially expressed between the paired tumor and normal tissues (1048 up and 1997 down). Meanwhile, our data showed that the expression NONHSAT077036 was associated with N classification and clinical stage. Further, we analyzed the potential co-regulatory relationship between the lncRNAs and their potential target genes using the ‘cis’ and ‘trans’ models. In the 25 related transcription factors (TFs), our analysis of The Cancer Genome Atlas database (TCGA) found that patients with lower expression of POU2F2 and higher expression of TRIM28 had a shorter overall survival time. The POU2F2 and TRIM28 co-expressed lncRNA landscape characterized here may shed light into normal biology and lung adenocarcinoma pathogenesis, and be valuable for discovery of biomarkers.
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DOI：
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发表时间：
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作者：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1016/j.gpb.2017.02.002
发表时间：
2017-04
期刊：
Genomics, proteomics & bioinformatics
影响因子：
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作者：
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