A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis
A suppressor T-lymphocyte cell line for autoimmune encephalomyelitis
复制标题
用于治疗自身免疫性脑脊髓炎的抑制性 T 淋巴细胞系
作者：
K. Ellerman;J. Powers;S. Brostoff
Experimental allergic encephalomyelitis (EAE) is a model for the in vitro and in vivo study of T-cell activation. It is an autoimmune disease mediated by T lymphocytes of the helper T-cell (Th) subset1,2. After sensitization to guinea-pig myelin basic protein in complete Freund's adjuvant, Lewis rats develop an autoimmune response to central nervous system (CNS) myelin basic protein, manifested clinically as paralysis and histologically by a perivas-cular mononuclear cell infiltrate of the CNS parenchyma. Suppressor cell regulation of EAE has long been suspected because Lewis rats, which spontaneously recover from active disease, are resistant to reinduction of active EAE, even though effector T-cell lines can be rescued from these recovered rats3. Using cyclosporin A, an immunosuppressive agent believed to inhibit Th cell function, suppressor T-cell (Ts) lines have now been generated from recovered Lewis rats. These Ts cells, when admixed with guinea pig myelin basic protein-specific Th cells, will prevent the adoptive transfer of EAE. The Ts cells appear to be CD4+, which explains previous observations that CD8+ lymphocytes are not important in the recovery of EAE in the rat. This is the first direct demonstration of Ts-cell regulation of EAE.
影响因子：
4.4
作者：
M. Blue;J. Daley;H. Levine;S. Schlossman
通讯作者：
M. Blue;J. Daley;H. Levine;S. Schlossman
W3/25 T 细胞介导心脏同种异体移植增强大鼠受体中免疫无反应的诱导。
DOI：
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发表时间：
1987
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Padberg,WM;Kupiec-Weglinski,JW;Lord,RH;Araneda,DH;Tilney,NL
通讯作者：
Tilney,NL