Behavioural phenotyping assays for mouse models of autism.
Behavioural phenotyping assays for mouse models of autism.
复制标题
自闭症小鼠模型的行为表型测定。
DOI：
10.1038/nrn2851
复制
发表时间：
2010-07
影响因子：
34.7
通讯作者：
Crawley, Jacqueline N.
中科院分区：
文献类型：
--
作者：
Silverman, Jill L.;Yang, Mu;Lord, Catherine;Crawley, Jacqueline N.
Autism is a heterogeneous neurodevelopmental disorder of unknown aetiology that affects 1 in 100–150 individuals. Diagnosis is based on three categories of behavioural criteria: abnormal social interactions, communication deficits and repetitive behaviours. Strong evidence for a genetic basis has prompted the development of mouse models with targeted mutations in candidate genes for autism. As the diagnostic criteria for autism are behavioural, phenotyping these mouse models requires behavioural assays with high relevance to each category of the diagnostic symptoms. Behavioural neuroscientists are generating a comprehensive set of assays for social interaction, communication and repetitive behaviours to test hypotheses about the causes of austism. Robust phenotypes in mouse models hold great promise as translational tools for discovering effective treatments for components of autism spectrum disorders.
登录
查看更多内容
影响因子：
64.8
作者：
Chen, GQ;Chen, KS;Morris, RGM
通讯作者：
Morris, RGM
影响因子：
2.7
作者：
Arakawa, Hiroyuki;Arakawa, Keiko;Blanchard, Robert J.
通讯作者：
Blanchard, Robert J.
影响因子：
2.9
作者：
Cheh, Michelle A.;Millonig, James H.;Wagner, George C.
通讯作者：
Wagner, George C.
影响因子：
4.7
作者：
Chadman, Kathryn K.;Gong, Shiaoching;Crawley, Jacqueline N.
通讯作者：
Crawley, Jacqueline N.
影响因子：
9.8
作者：
Benayed, R;Gharani, N;Millonig, JH
通讯作者：
Millonig, JH