Relationships between chemical structure and inhibition of ADP-stimulated human thrombocyte release of serotonin and platelet factor 4.
Relationships between chemical structure and inhibition of ADP-stimulated human thrombocyte release of serotonin and platelet factor 4.
复制标题
化学结构与 ADP 刺激的人血小板释放血清素和血小板因子 4 的抑制之间的关系。
DOI：
10.1016/s0304-4165(89)80023-6
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Gollamudi,R
中科院分区：
文献类型：
--
作者：
Dillingham,EO;Lasslo,A;Carter-Burks,G;Bond,SE;Gollamudi,R
本文研究了氨基甲酰哌啶烷和N-烷基哌啶甲酰基哌嗪衍生物对二磷酸腺苷（ADP）诱导的人血小板聚集、5-羟色胺（5-HT）释放和血小板第四因子（PF-4）释放的抑制作用。该程序旨在允许同时测定所有三组值。大多数化合物在阻断PF-4方面的效力超过两倍（X = 91 ± 1（S.E.，n= 1）%）与其对5-HT的抑制作用（X= 38 ± 1（SE，n= 6）%）释放;未能满足这些标准的一种化合物在阻止PF-4释放方面仍然明显比5-HT更强。由于化合物的血小板聚集抑制值与其5-HT释放阻断效力在相同范围内，但在阻止PF-4释放方面具有显著更大的影响，因此表明血小板质膜和包裹致密体的衬里可能具有某些共性，而包裹α颗粒的鞘可能以有形的方式不同于两者。
The inhibitory potencies of carbamoylpiperidinoalkane andN-alkylnipecotoylpiperazine derivatives on ADP-stimulated human blood platelet aggregation, serotonin (5-HT) release and platelet factor 4 (PF-4) release were evaluated. The procedure was designed to allow concurrent determination of all three sets of values. Most compounds were more than twice as potent in blocking PF-4 (X = 91 ± 1(S.E.,n= 1)%) compared to their inhibition of 5-HT (X= 38 ± 1(S.E.,n= 6)%) release; the one compound which failed to meet these criteria was still decidedly more powerful in impeding PF-4 than 5-HT release. Since the compounds' platelet aggregation-inhibitory values were within the same range as their 5-HT release-blocking potencies, but had a strikingly greater impact in arresting PF-4 release, it is suggested that the platelet plasma membrane and the lining enveloping the dense bodies may share certain commonalities, while the sheathing encasing theα-granules may differ from both in a tangible manner.
登录
查看更多内容
β-血栓球蛋白 (β-TG) 和血小板因子 4 (PF4) 通过二磷酸腺苷 (ADP) 与天然全血接触而释放。
影响因子：
7.5
作者：
V. Pengo;M. Boschello;P. Prandoni;L. Schivazappa;A. Girolami
通讯作者：
A. Girolami
血小板分泌α颗粒的动力学分析方法学报告。
影响因子：
7.5
作者：
J. Akkerman;G. Gorter;E. Kloprogge
通讯作者：
E. Kloprogge
人血小板因子 4：亚细胞定位和完整血小板释放的特征。
影响因子：
7.5
作者：
R. Ryo;R. Proffitt;T. Deuel
通讯作者：
T. Deuel
血小板 5-羟色胺系统：生理学和病理生理学。
影响因子：
3.5
作者：
A. Pletscher
通讯作者：
A. Pletscher
影响因子：
20.1
作者：
WITTE, LD;KAPLAN, KL;GOODMAN, DS
通讯作者：
GOODMAN, DS