Cortico-subcortical interactions in overlapping communities of edge functional connectivity.
Cortico-subcortical interactions in overlapping communities of edge functional connectivity.
复制标题
边缘功能连通性重叠社区中的皮质 - 皮质相互作用。
DOI：
10.1016/j.neuroimage.2022.118971
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发表时间：
2022-04-15
期刊：
影响因子：
5.7
通讯作者：
Sporns, Olaf
中科院分区：
文献类型：
--
作者：
Chumin, Evgeny J.;Faskowitz, Joshua;Esfahlani, Farnaz Zamani;Jo, Youngheun;Merritt, Haily;Tanner, Jacob;Cutts, Sarah A.;Pope, Maria;Betzel, Richard;Sporns, Olaf
大脑皮层和皮质下区域都可以在功能上组织成网络。基底节的区域通过传递和调节皮质功能的相互连接广泛地与皮质相互连接。在这里，我们使用以边缘为中心的方法，计算网络中区域对之间的共同波动，以研究皮质下区域与皮质系统的作用和相互作用。通过将边缘聚类成群落，我们发现皮质系统和皮质下区域通过多个边缘群落耦合，其中海马体和杏仁核与纹状体和丘脑具有不同的模式。我们发现，当网络中存在皮质下时，皮质网络的边缘群落结构与从皮质节点获得的边缘群落结构高度相似。此外，我们表明，皮质和皮质下节点的边缘群落轮廓可以仅通过皮质-皮质下相互作用来估计。最后，我们使用了专注于边缘社区三联体的主题分析，其中一个皮质下区域耦合到两个皮质区域，并发现两个社区三联体中一个社区将皮质下连接到皮质的比例过高。综上所述，我们的结果表明，皮层下与皮质之间的有组织的耦合可能在初级感觉运动/注意系统和异形神经系统的皮质组织中发挥作用，并提出边缘社区三联体的主题分析是一种很有前途的网络交流模式研究方法。
Both cortical and subcortical regions can be functionally organized into networks. Regions of the basal ganglia are extensively interconnected with the cortex via reciprocal connections that relay and modulate cortical function. Here we employ an edge-centric approach, which computes co-fluctuations among region pairs in a network to investigate the role and interaction of subcortical regions with cortical systems. By clustering edges into communities, we show that cortical systems and subcortical regions couple via multiple edge communities, with hippocampus and amygdala having a distinct pattern from striatum and thalamus. We show that the edge community structure of cortical networks is highly similar to one obtained from cortical nodes when the subcortex is present in the network. Additionally, we show that the edge community profile of both cortical and subcortical nodes can be estimates solely from cortico-subcortical interactions. Finally, we used a motif analysis focusing on edge community triads where a subcortical region coupled to two cortical regions and found that two community triads where one community couples the subcortex to the cortex were overrepresented. In summary, our results show organized coupling of the subcortex to the cortex that may play a role in cortical organization of primary sensorimotor/attention and heteromodal systems and puts forth the motif analysis of edge community triads as a promising method for investigation of communication patterns in networks.
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影响因子：
3.1
作者：
Di, Xin;Biswal, Bharat B.
通讯作者：
Biswal, Bharat B.
DOI：
10.1073/pnas.1220826110
发表时间：
2013-07-09
影响因子：
11.1
作者：
Crossley, Nicolas A.;Mechelli, Andrea;Bullmore, Edward T.
通讯作者：
Bullmore, Edward T.
影响因子：
25.8
作者：
Cerliani, Leonardo;Mennes, Maarten;Thomas, Rajat M.;Di Martino, Adriana;Thioux, Marc;Keysers, Christian
通讯作者：
Keysers, Christian
影响因子：
4.2
作者：
Contreras, Joey A.;Avena-Koenigsberger, Andrea;Sporns, Olaf
通讯作者：
Sporns, Olaf
影响因子：
5.8
作者：
Bostan, Andreea C.;Strick, Peter L.
通讯作者：
Strick, Peter L.