Adult neurogenesis improves spatial information encoding in the mouse hippocampus
Adult neurogenesis improves spatial information encoding in the mouse hippocampus
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成年神经发生改善了小鼠海马体的空间信息编码
DOI：
10.1101/2022.11.30.518622
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
J. T. Gonçalves
中科院分区：
文献类型：
--
作者：
M. A. Frechou;Sunaina S. Martin;Kelsey D. McDermott;Ş. Gökhan;W. Tomé;Ruben Coen;J. T. Gonçalves
成体神经发生是神经元可塑性的一种独特形式，其中新产生的神经元在受环境刺激调节的过程中整合到成体齿状回中。成年人的神经元可以促进空间记忆，但尚不清楚它们是否会改变海马体中空间的神经表征。使用体内双光子钙成像，我们发现，小鼠先前被安置在一个丰富的环境中，这触发了神经发生的增加，增加了空间信息编码在海马齿状回在新的背景曝光。通过海马的预先局灶性照射来消除成年神经发生阻断了富集的效果，降低了空间信息含量，就像成年出生的神经元的化学发生沉默一样。消融神经发生和沉默成年出生的神经元降低了齿状回神经元的钙活性率，导致位置特异性反应的幅度降低。这些发现与以前的研究相反，这些研究表明成年出生的神经元主要具有抑制作用。我们认为，成人神经发生通过增加齿状回神经元的增益来改善空间的神经表征，从而提高它们对空间特征的调节能力。这种机制可能介导了丰富的环境对空间学习和记忆的有益影响。
Adult neurogenesis is a unique form of neuronal plasticity in which newly generated neurons are integrated into the adult dentate gyrus in a process that is modulated by environmental stimuli. Adult-born neurons can contribute to spatial memory but it is unknown whether they alter neural representations of space in the hippocampus. Using in vivo two-photon calcium imaging, we found that mice that were previously housed in an enriched environment, which triggers an increase in neurogenesis, had increased spatial information encoding in the hippocampal dentate gyrus during novel context exposure. Ablating adult neurogenesis by prior focal irradiation of the hippocampus blocked the effect of enrichment and lowered spatial information content, as did the chemogenetic silencing of adult-born neurons. Both ablating neurogenesis and silencing adult-born neurons decreased the calcium activity rates of dentate gyrus neurons, resulting in a decreased amplitude of place-specific responses. These findings are in contrast to previous studies that suggested a predominantly inhibitory action for adult-born neurons. We propose that adult neurogenesis improves neural representations of space by increasing the gain of dentate gyrus neurons and thereby improving their ability to tune to spatial features. This mechanism may mediate the beneficial effects of environmental enrichment on spatial learning and memory.
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影响因子：
64.8
作者：
Hainmueller T;Bartos M
通讯作者：
Bartos M
影响因子：
29
作者：
Vemuri, Prashanthi;Lesnick, Timothy G.;Przybelski, Scott A.;Machulda, Mary;Knopman, David S.;Mielke, Michelle M.;Roberts, Rosebud O.;Geda, Yonas E.;Rocca, Walter A.;Petersen, Ronald C.;Jack, Clifford R., Jr.
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Jack, Clifford R., Jr.
影响因子：
25
作者：
Verhoef BE;Maunsell JHR
通讯作者：
Maunsell JHR
影响因子：
13.9
作者：
Kohn A;Coen-Cagli R;Kanitscheider I;Pouget A
通讯作者：
Pouget A
DOI：
10.1073/pnas.1015425108
发表时间：
2011-03-29
影响因子：
11.1
作者：
Singer, Benjamin H.;Gamelli, Amy E.;Murphy, Geoffrey G.
通讯作者：
Murphy, Geoffrey G.