Mitochondrial quality control in the diabetic heart.
Mitochondrial quality control in the diabetic heart.
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DOI：
10.1016/j.yjmcc.2015.12.025
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发表时间：
2016-06
影响因子：
5
通讯作者：
Kobayashi S
中科院分区：
文献类型：
--
作者：
Liang Q;Kobayashi S
糖尿病是众所周知的心力衰竭的危险因素。糖尿病心脏损害与线粒体功能障碍和ROS生成增加密切相关。然而，临床试验显示抗氧化剂治疗对糖尿病患者的心力衰竭没有影响，这表明简单地通过抗氧化剂拮抗现有的ROS不足以减少糖尿病心脏损伤。一种可能更有效的治疗策略可能是增强线粒体质量控制的整体能力，以维持支持糖尿病患者心脏收缩功能所需的健康线粒体库。线粒体的质量是由许多协调机制控制的，包括线粒体分裂和融合、线粒体自噬和生物发生。在糖尿病心脏中始终观察到的线粒体损伤表明线粒体质量控制机制的失败。最近的研究表明，这些机制中的每一个在心脏内稳态中起着至关重要的作用，并已开始询问线粒体质量控制不足对糖尿病心脏损伤的相对贡献。在这篇综述中，我们将介绍目前可用的文献，糖尿病性心脏病的主要线粒体质量控制机制的失调。我们将讨论这些机制在糖尿病心脏病发病机制中的功能作用及其靶向治疗操作的潜力。
Diabetes is a well known risk factor for heart failure. Diabetic heart damage is closely related to mitochondrial dysfunction and increased ROS generation. However, clinical trials have shown no effects of antioxidant therapies on heart failure in diabetic patients, suggesting that simply antagonizing existing ROS by antioxidants is not sufficient to reduce diabetic cardiac injury. A potentially more effective treatment strategy may be to enhance the overall capacity of mitochondrial quality control to maintain a pool of healthy mitochondria that are needed for supporting cardiac contractile function in diabetic patients. Mitochondrial quality is controlled by a number of coordinated mechanisms including mitochondrial fission and fusion, mitophagy and biogenesis. The mitochondrial damage consistently observed in the diabetic hearts indicates a failure of the mitochondrial quality control mechanisms. Recent studies have demonstrated a crucial role for each of these mechanisms in cardiac homeostasis and have begun to interrogate the relative contribution of insufficient mitochondrial quality control to diabetic cardiac injury. In this review, we will present currently available literature that links diabetic heart disease to the dysregulation of major mitochondrial quality control mechanisms. We will discuss the functional roles of these mechanisms in the pathogenesis of diabetic heart disease and their potentials for targeted therapeutical manipulation.
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影响因子：
3.4
作者：
Dorn GW 2nd
通讯作者：
Dorn GW 2nd
影响因子：
4.5
作者：
Ashrafian H;Docherty L;Leo V;Towlson C;Neilan M;Steeples V;Lygate CA;Hough T;Townsend S;Williams D;Wells S;Norris D;Glyn-Jones S;Land J;Barbaric I;Lalanne Z;Denny P;Szumska D;Bhattacharya S;Griffin JL;Hargreaves I;Fernandez-Fuentes N;Cheeseman M;Watkins H;Dear TN
通讯作者：
Dear TN
DOI：
10.1073/pnas.0603615103
发表时间：
2006-06-27
影响因子：
11.1
作者：
Arany, Zoltan;Novikov, Mikhail;Spiegelman, Bruce M.
通讯作者：
Spiegelman, Bruce M.
影响因子：
7.1
作者：
Fernandez-Marcos, Pablo J.;Auwerx, Johan
通讯作者：
Auwerx, Johan
影响因子：
5.4
作者：
Chen L;Liu T;Tran A;Lu X;Tomilov AA;Davies V;Cortopassi G;Chiamvimonvat N;Bers DM;Votruba M;Knowlton AA
通讯作者：
Knowlton AA