JCAD expression and localization in human blood endothelial cells.
JCAD expression and localization in human blood endothelial cells.
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DOI：
10.1016/j.heliyon.2020.e05121
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发表时间：
2020-10
期刊：
影响因子：
4
通讯作者：
Akashi M
中科院分区：
文献类型：
--
作者：
Shigeoka M;Arimoto S;Akashi M
Junctional Cadherin 5 Associated（JCAD）是一种内皮细胞-细胞连接蛋白，其表达与包括动脉粥样硬化和高血压在内的心血管疾病相关。然而，迄今为止，很少有研究证实JCAD表达和精确定位在人体组织中的免疫组化染色。通过免疫组织化学染色评估了4例人下颌下腺（SMG）标本中JCAD的表达和定位。一例SMG伴涎腺炎的标本伴有严重炎症和纤维化，而另一例基本正常。另2例SMG患者因照射导致严重纤维化。人SMG的免疫组织化学分析显示JCAD定位于血液内皮细胞-细胞连接处。JCAD表达在炎症影响区域的微血管和动脉中更明显。在人体组织中证实了JCAD在内皮细胞-细胞连接处的定位。JCAD表达可能受病理条件的影响。JCAD（连接钙粘蛋白5相关）;血内皮细胞-细胞连接;炎症;颌下腺;心脏病学;心血管系统;病理学;口腔医学
Junctional Cadherin 5 Associated (JCAD) is an endothelial, cell-cell junction protein, and its expression is associated with cardiovascular diseases including atherosclerosis and hypertension. However, to date, there are few studies confirming JCAD expression and precise localization in human tissues by immunohistochemical staining. JCAD expression and localization was assessed in four human submandibular gland (SMG) specimens by immunohistochemical staining. One specimen of SMG with sialoadenitis was accompanied by severe inflammation and fibrosis, while the other was largely normal. Other two SMGs were accompanied by severe fibrosis because of irradiation. Immunohistochemical analysis of human SMGs revealed JCAD localization at the blood endothelial cell-cell junctions. JCAD expression was more evident in microvessels and arteries in areas affected by inflammation. The localization of JCAD at endothelial cell-cell junctions was confirmed in human tissues. JCAD expression may be affected by pathological conditions. JCAD (junctional cadherin 5 associated); Blood endothelial cell-cell junction; Inflammation; Submandibular gland; Cardiology; Cardiovascular system; Pathology; Oral medicine
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影响因子：
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作者：
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DOI：
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影响因子：
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