Development of Galectin-3 Targeting Drugs for Therapeutic Applications in Various Diseases.
Development of Galectin-3 Targeting Drugs for Therapeutic Applications in Various Diseases.
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DOI：
10.3390/ijms24098116
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发表时间：
2023-05-01
影响因子：
5.6
通讯作者：
Ahmed, Hafiz
中科院分区：
文献类型：
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作者：
Ahmed, Rakin;Anam, Khairul;Ahmed, Hafiz
半乳糖凝集素-3（Gal 3）是半乳糖凝集素家族中研究最多的成员之一，其介导多种生物学过程，如生长调节、免疫功能、癌症转移和细胞凋亡。由于Gal 3是促炎性的，它参与了许多与慢性炎症相关的疾病，如癌症，器官纤维化和2型糖尿病。Gal 3作为一种多功能蛋白质，参与多种疾病的多个通路，在制药工业中引起了极大的兴趣。因此，正在开发几种Gal 3靶向治疗药物以解决未满足的医疗需求。基于PubMed检索Gal 3到目前为止（1987-2023），在这里，我们简要描述了它的结构，碳水化合物结合特性，内源性配体和在各种疾病中的作用。我们还讨论了其潜在的拮抗剂，目前正在研究临床或临床前的公共和私营公司。关于Gal 3在各种疾病中的功能的最新知识可以启动新的临床或临床前研究以测试治疗策略，并且这些策略中的一些可以是成功的，并且被认为是用于未满足的医疗需求的新型疗法。
Galectin-3 (Gal3) is one of the most studied members of the galectin family that mediate various biological processes such as growth regulation, immune function, cancer metastasis, and apoptosis. Since Gal3 is pro-inflammatory, it is involved in many diseases that are associated with chronic inflammation such as cancer, organ fibrosis, and type 2 diabetes. As a multifunctional protein involved in multiple pathways of many diseases, Gal3 has generated significant interest in pharmaceutical industries. As a result, several Gal3-targeting therapeutic drugs are being developed to address unmet medical needs. Based on the PubMed search of Gal3 to date (1987–2023), here, we briefly describe its structure, carbohydrate-binding properties, endogenous ligands, and roles in various diseases. We also discuss its potential antagonists that are currently being investigated clinically or pre-clinically by the public and private companies. The updated knowledge on Gal3 function in various diseases could initiate new clinical or pre-clinical investigations to test therapeutic strategies, and some of these strategies could be successful and recognized as novel therapeutics for unmet medical needs.
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