Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review.
Etiology, microbiological isolates, and antibiotic susceptibilities in culture-proven pediatric endophthalmitis: a 9-year review.
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培养证实的儿科眼内炎的病因、微生物分离株和抗生素敏感性：9 年回顾
DOI：
10.1007/s00417-020-04866-7
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Lin X
中科院分区：
文献类型：
--
作者：
Yang Y;Lin L;Li Y;Jiang Z;Li C;Liu M;Duan F;Lin X
PurposeTo analyze the etiology, microbiological isolates, and antibiotic susceptibilities of endophthalmitis in pediatric patients.MethodsPatients aged < 18 years with culture-positive endophthalmitis in Zhongshan Ophthalmic Center between January 2010 and December 2018 were included retrospectively.ResultsA total of 127 patients (127 eyes) were included, and 108 (85%) had posttraumatic endophthalmitis.Streptococcus(21.4%), coagulase-negativeStaphylococcus(14.5%),Aspergillus(6.9%), andBacillus cereus(5.3%) were the common organisms. The proportion ofStreptococcusdecreased with age (40.0% in 0–3 years, 16.3% in 4–12 years, and 6.3% in 13–17 years), while coagulase-negativeStaphylococcusincreased from 5.7% to 18.8%. Overall, fluoroquinolones achieved the highest antibiotic susceptibility rate (> 95%), while the susceptibility of isolated bacteria to tobramycin and cefazolin was only 60.2% and 59.4%, respectively. The susceptibility rates of Gram-positive cocci to cephalosporins were nearly 90%. For Gram-negative bacilli, susceptibility to neomycin was 91.3%.ConclusionTrauma was the main etiology for pediatric endophthalmitis. AlthoughStreptococcuswas the most prevalent organism in general, the dominant pathogen varied with age, which merits clinical attention. Fluoroquinolones showed the highest antibiotic efficacy; however, commonly used antibiotics tobramycin and cefazolin showed relatively low antibiotic susceptibility. Thus, antibiotic resistance in pediatric populations merits clinical attention.
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