Role of interleukins, IGF and stem cells in BPH.
Role of interleukins, IGF and stem cells in BPH.
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DOI：
10.1016/j.diff.2011.06.001
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发表时间：
2011-11
期刊：
影响因子：
2.9
通讯作者：
Bushman, Wade
中科院分区：
文献类型：
--
作者：
McLaren, Ian D.;Jerde, Travis J.;Bushman, Wade
被称为良性前列腺增生的病症可以被定义为由良性上皮和基质成分两者的增殖引起的前列腺的良性增大。临床上也可定义为老年男性的下尿路症状（LUTS）。本综述的目的是考虑属于白细胞介素家族的炎症细胞因子，IFG家族成员和干细胞可能有助于BPH-LUTS的发展和进展的方式。这可能发生在三个机制：一，白细胞介素信号，IFG信号和干细胞可能有助于重新激活的发育生长机制在成人前列腺导致组织生长。第二，鉴于流行病学研究表明BPH-LUTS的发病率增加与肥胖和糖尿病有关，IFG信号可能为糖尿病和肥胖对前列腺生长的影响提供了机制基础。第三，与前列腺炎症相关的白细胞介素的表达可诱导支配前列腺的传入纤维的敏化，并导致前列腺和膀胱对疼痛和有害感觉的敏感性增加，以及对膀胱充盈的敏感性增加。
The condition known as benign prostatic hyperplasia may be defined as a benign enlargement of the prostate gland resulting from a proliferation of both benign epithelial and stromal elements. It might also be defined clinically as a constellation of lower urinary tract symptoms (LUTSs) in aging men. The purpose of this review is to consider the ways in which inflammatory cytokines belonging to the interleukin family, members of the IFG family, and stem cells may contribute to the development and progression of BPH-LUTS. This might occur in three mechanisms: One, interleukin signaling, IFG signaling and stem cells may contribute to reactivation of developmental growth mechanisms in the adult prostate leading to tissue growth. Two, given that epidemiologic studies indicate an increased incidence of BPH-LUTS in association with obesity and diabetes, IFG signaling may provide the mechanistic basis for the effect of diabetes and obesity on prostate growth. Three, expression of interleukins in association with inflammation in the prostate may induce sensitization of afferent fibers innervating the prostate and result in increased sensitivity to pain and noxious sensations in the prostate and bladder and heightened sensitivity to bladder filling.
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