Short sleep duration and incident coronary artery calcification.
Short sleep duration and incident coronary artery calcification.
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DOI：
10.1001/jama.2008.867
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发表时间：
2008-12-24
影响因子：
120.7
通讯作者：
Lauderdale, Diane S.
中科院分区：
文献类型：
--
作者：
King, Christopher Ryan;Knutson, Kristen L.;Rathouz, Paul J.;Sidney, Steve;Liu, Kiang;Lauderdale, Diane S.
冠状动脉钙化是冠心病的亚临床预测因子。最近的研究发现，睡眠时间与钙化的既定风险因素相关，包括血糖调节，血压，性别，年龄，教育和体重指数。确定睡眠持续时间和质量的客观和主观指标是否与5年内钙化的发生率相关，以及钙化风险因素是否介导了这种相关性。2000-2006年观察组群。在基线和随访时测量潜在混杂因素（年龄、性别、种族、教育、呼吸暂停风险、吸烟状况）和介质（血脂、血压、体重指数、糖尿病、炎症标志物、酒精、抑郁、敌意、自我报告的医疗状况）。我们检查了睡眠指标（腕动计测量的持续时间和碎片，白天嗜睡，整体质量，自我报告的持续时间）与事件钙化的关联。健康中年人群的家庭监测。来自CARDIA队列芝加哥研究中心的494名受试者（基线时年龄为35-47岁的非裔美国人和白色男性和女性），具有睡眠、人口统计学和钙化测量结果，且基线时未检测到钙化。在2000-2001年和2005-2006年通过CT测量冠状动脉钙化;这段时间内新钙化的发生率是主要结局。5年钙化发生率为12.3%（n=61）。较长的测量睡眠时间与钙化的调整几率降低显著相关（OR = 0.67/小时，p= 0.011; 95%CI 0.49-0.91）。没有潜在的介质明显改变睡眠的大小或意义（调整后的OR估计值范围为每睡眠小时0.64至0.68，最大p值= 0.020）。其他睡眠指标与钙化无显著相关性。较长的测量睡眠与较低的钙化发生率相关，独立于检查的潜在介质和混杂因素。
Coronary artery calcification is a subclinical predictor of coronary heart disease. Recent studies have found that sleep duration is correlated with established risk factors for calcification including glucose regulation, blood pressure, sex, age, education, and body mass index. To determine whether objective and subjective measures of sleep duration and quality are associated with incidence of calcification over five years and whether calcification risk factors mediate the association. Observational cohort 2000–2006. Potential confounders (age, sex, race, education, apnea risk, smoking status) and mediators (lipids, blood pressure, body mass index, diabetes, inflammatory markers, alcohol, depression, hostility, self reported medical conditions) were measured at both baseline and follow-up. We examined sleep metrics (wrist actigraphy measured duration and fragmentation, daytime sleepiness, overall quality, self-reported duration) for association with incident calcification. Home monitoring of healthy middle-aged population. 494 participants from the CARDIA cohort Chicago site (African American and white men and women aged 35–47 at baseline) with sleep, demographic and calcification measurements and no detectable baseline calcification. Coronary artery calcification was measured by CT in 2000–2001 and 2005–2006; incidence of new calcification over that time was the primary outcome. Five-year calcification incidence was 12.3% (n=61). Longer measured sleep duration was significantly associated with decreased adjusted odds of calcification (OR = 0.67 per hour, p=.011; 95% CI 0.49–0.91). No potential mediators appreciably altered the magnitude or significance of sleep (adjusted OR estimates ranged from 0.64 to 0.68 per sleep hour, maximum p-value=.020). Alternative sleep metrics were not significantly associated with calcification. Longer measured sleep is associated with lower calcification incidence independently of examined potential mediators and confounders.
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影响因子：
3.1
作者：
EVANS, PD;MORAN, P
通讯作者：
MORAN, P
影响因子：
9.6
作者：
Garcia-Diaz, Emilio;Quintana-Gallego, Esther;Capote, Francisco
通讯作者：
Capote, Francisco
影响因子：
158.5
作者：
Detrano, Robert;Guerci, Alan D.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
DOI：
10.1016/0735-1097(90)90282-t
发表时间：
1990-03-15
影响因子：
24
作者：
AGATSTON, AS;JANOWITZ, WR;DETRANO, R
通讯作者：
DETRANO, R
影响因子：
4.7
作者：
Hann, D;Winter, K;Jacobsen, P
通讯作者：
Jacobsen, P