Kinetics of glycoxidation of bovine serum albumin by methylglyoxal and glyoxal and its prevention by various compounds.
Kinetics of glycoxidation of bovine serum albumin by methylglyoxal and glyoxal and its prevention by various compounds.
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DOI：
10.3390/molecules19044880
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发表时间：
2014-04-17
期刊：
影响因子：
--
通讯作者：
Bartosz G
中科院分区：
文献类型：
--
作者：
Sadowska-Bartosz I;Galiniak S;Bartosz G
本研究的目的是比较几种方法的测量牛血清白蛋白（BSA）的糖基化与反应性二羰基化合物（甲基乙二醛MGO和乙二醛MGO）的修饰，这个过程的动力学研究，并比较19个选定的化合物对BSA的醛糖化的影响。结果证实MGO相对于GO具有更高的反应性，并指出AGE、二酪氨酸和N′-甲酰犬尿氨酸荧光可用于监测糖化和评价针对糖化的保护。不同程度的保护对由MGO和GO诱导的糖基化被发现对于许多化合物，可能反映了对糖基化过程的各个阶段的影响。多酚类物质（染料木黄酮，柚皮苷和鞣花酸）被发现，以防止对甜菜碱诱导的糖化; 1-氰基-4-羟基肉桂酸也是一种有效的保护。
The aim of this study was to compare several methods for measurement of bovine serum albumin (BSA) modification by glycoxidation with reactive dicarbonyl compounds (methylglyoxal ‒ MGO and glyoxal ‒ GO), for studies of the kinetics of this process and to compare the effects of 19 selected compounds on BSA glycation by the aldehydes. The results confirm the higher reactivity of MGO with respect to GO and point to the usefulness of AGE, dityrosine and N′-formylkynurenine fluorescence for monitoring glycation and evaluation of protection against glycation. Different extent of protection against glycation induced by MGO and GO was found for many compounds, probably reflecting effects on various stages of the glycation process. Polyphenols (genistein, naringin and ellagic acid) were found to protect against aldehyde-induced glycation; 1-cyano-4-hydroxycinnamic acid was also an effective protector.
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DOI：
10.1016/j.cca.2013.07.013
发表时间：
2013-10-21
期刊：
Clinica chimica acta; international journal of clinical chemistry
影响因子：
--
作者：
Anguizola J;Matsuda R;Barnaby OS;Hoy KS;Wa C;DeBolt E;Koke M;Hage DS
通讯作者：
Hage DS
影响因子：
4.1
作者：
Briski, KP;Patil, GD
通讯作者：
Patil, GD
影响因子：
3.9
作者：
KRISHNA, CM;LIEBMANN, JE;RUSSO, A
通讯作者：
RUSSO, A
影响因子：
2.2
作者：
Ishibashi, Y.;Matsui, T.;Yamagishi, S.
通讯作者：
Yamagishi, S.
影响因子：
9.8
作者：
Diamanti-Kandarakis, Evanthia;Alexandraki, Krystallenia;Panidis, Dimitrios
通讯作者：
Panidis, Dimitrios