Fabrication of Al2O3 by anodic oxidation and hydrothermal synthesis of strong-bonding hydroxyapatite coatings on its surface
Fabrication of Al2O3 by anodic oxidation and hydrothermal synthesis of strong-bonding hydroxyapatite coatings on its surface
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阳极氧化制备Al2O3并水热合成其表面强结合羟基磷灰石涂层
DOI：
10.1016/j.apsusc.2018.11.216
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发表时间：
2019-03
影响因子：
6.7
通讯作者：
Fuzhen He
中科院分区：
文献类型：
--
作者：
Xueni Zhao;Weigang Zhang;Yao Wang;Qingyao Liu;Jianjun Yang;Li Zhang;Fuzhen He
由于优异的机械性能和生物相容性，A12O3被认为是一种有前途的生物医学应用生物材料。然而，A12O3固有的生物惰性限制了其更广泛的应用。虽然在Al2O3上涂覆生物活性羟基磷灰石(HA)涂层是提高表面生物活性的有效方法，但HA涂层与平坦的Al2O3基体之间的结合强度较低。本研究通过阳极氧化制备了具有微孔表面结构和亲水表面的Al2O3，以提高HA涂层与Al2O3之间的结合强度。然后，通过水热合成法在多孔Al2O3上制备了强结合的HA涂层。结果表明，随着电流密度和氧化时间的增加，Al2O3表面孔分布的均匀性和润湿性显着提高。采用7mA/cm2阳极氧化4h制备多孔Al2O3，孔径为4.3~7.1μm，接触角为42.2±2.6°。通过180℃水热合成24h，纳米棒状HA涂层完全均匀地覆盖在Al2O3表面。 HA涂层的厚度接近30±1.01μm，HA涂层与Al2O3之间的界面没有分层和/或开裂。多孔Al2O3上HA涂层的最高结合强度为18.3±2.4MPa，高于其他方法在平面Al2O3上形成的HA涂层。此外，模拟体液（SBF）浸泡试验表明HA包覆的Al2O3具有优异的体外生物活性。因此，具有生物活性HA涂层的Al2O3可以成为生物医学应用的候选生物材料。
Due to excellent mechanical properties and biocompatibility, A12O3is considered as a promising biomaterial for biomedical applications. However, the inherent bio-inertness of A12O3have limited its wider application. Although applying bioactive hydroxyapatite (HA) coatings on Al2O3is an effective method to improve surface bioactivity, the bonding strength between the HA coatings and the flat A12O3substrate is low. In this study, Al2O3with micro-porous surface structure and hydrophilic surface was fabricated by anodic oxidation to improve the bonding strength between HA coatings and Al2O3. Then, strong-bonding HA coatings were prepared on the porous Al2O3by hydrothermal synthesis. The results reveal the uniformity of pore distribution and the wettability of Al2O3surface are significantly improved with the increase of current density and oxidation time. When the porous Al2O3is prepared by anodic oxidation at 7 mA/cm2for 4 h, the diameter of pores is 4.3–7.1 μm and the porous Al2O3has a contact angle of 42.2 ± 2.6°. Nano-rod-like HA coatings completely and uniformly cover the surface of Al2O3by hydrothermal synthesis at 180 °C for 24 h. The thickness of HA coatings is almost 30 ± 1.01 μm without delamination and/or cracking at the interface between HA coatings and Al2O3. The highest bonding strength of HA coatings on porous Al2O3is 18.3 ± 2.4 MPa, which is higher than that of HA coatings formed on flat Al2O3by other methods. In addition, simulated body fluid (SBF) immersion tests indicate that HA-coated Al2O3possesses excellent biological activity in vitro. Hence, Al2O3with bioactive HA coatings could be a candidate biomaterial for biomedical applications.
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DOI：
10.1016/j.jmbbm.2017.03.003
发表时间：
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影响因子：
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作者：
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