Lung pericytes as mediators of inflammation.
Lung pericytes as mediators of inflammation.
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DOI：
10.1152/ajplung.00354.2022
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发表时间：
2023-07-01
期刊：
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周细胞是直接接触内皮细胞的微血管壁细胞。它们在血管发育和体内平衡中的作用早已被认识到，但最近已被确定为宿主对损伤反应的关键介质。在这种情况下，周细胞具有令人惊讶的细胞可塑性程度，动态行为时，激活和潜在地参与了一系列不同的主机响应损伤。虽然已经有很多的兴趣在纤维化和组织修复中的周细胞的作用，他们在最初的炎症过程中的参与已经研究不足，越来越多的赞赏。周细胞通过白细胞运输和细胞因子信号传导介导炎症，响应病原体相关分子模式和组织损伤相关分子模式，并可能在人类SARS-CoV-2感染期间驱动血管炎症。在这篇综述中，我们强调了器官损伤过程中激活的周细胞的炎症表型，重点是与肺病理生理学相关的新发现。
Pericytes are microvascular mural cells that directly contact endothelial cells. They have long been recognized for their roles in vascular development and homeostasis, but more recently have been identified as key mediators of the host response to injury. In this context, pericytes possess a surprising degree of cellular plasticity, behaving dynamically when activated and potentially participating in a range of divergent host responses to injury. Although there has been much interest in the role of pericytes in fibrosis and tissue repair, their involvement in the initial inflammatory process has been understudied and is increasingly appreciated. Pericytes mediate inflammation through leukocyte trafficking and cytokine signaling, respond to pathogen-associated molecular patterns and tissue damage-associated molecular patterns, and may drive vascular inflammation during human SARS-CoV-2 infection. In this review, we highlight the inflammatory phenotype of activated pericytes during organ injury, with an emphasis on novel findings relevant to pulmonary pathophysiology.
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DOI：
10.1152/ajplung.00392.2021
发表时间：
2022-04-01
期刊：
American journal of physiology. Lung cellular and molecular physiology
影响因子：
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作者：
Hung CF;Wilson CL;Chow YH;Liles WC;Gharib SA;Altemeier WA;Schnapp LM
通讯作者：
Schnapp LM
影响因子：
4.8
作者：
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Sanz, Laura
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影响因子：
7.7
作者：
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Brownlee M
影响因子：
56.9
作者：
Goritz, Christian;Dias, David O.;Frisen, Jonas
通讯作者：
Frisen, Jonas
影响因子：
6
作者：
Bondjers, C;Kalén, M;Betsholtz, C
通讯作者：
Betsholtz, C