Measuring technetium-99m-MAG3 clearance with an improved camera-based method.
Measuring technetium-99m-MAG3 clearance with an improved camera-based method.
复制标题
使用改进的基于相机的方法测量 technetium-99m-MAG3 间隙。
DOI：
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复制
发表时间：
1995
影响因子：
9.3
通讯作者：
D. Eshima
中科院分区：
文献类型：
--
作者：
A. M. Taylor;P. Corrigan;J. Galt;Ernest V. Garcia;R. Folks;M. Jones;A. Manatunga;D. Eshima
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由于商业上可用的基于相机的方法没有得到优化，它们无法考虑剂量渗透、表衰减以及注射时间和启动相机之间的对应关系。我们开发了一种更优化的基于相机的间隙计算技术，并将该技术应用于99mTC-MAG3的基于相机的间隙方法的设计中。
方法
对20例不同程度肾功能的患者行~(99m)Tm-MAG_3核素显像。仰卧位患者以2秒/帧24帧、15秒/帧16帧和30秒/帧40帧的速度采集数据。使用自动椭圆形感兴趣区域进行背景校正。使用改进的回归方程和来自模体研究的经验性确定的衰减系数来估计肾脏深度。对表衰减和剂量注射与启动相机之间的时间差异进行了修正。肾注射后1-2、1-2.5和2-3min的百分比注射剂量和校正后的体表面积的这些时间段的百分比注射剂量与MAG3清除量按一次注射二室模型关联。
结果
三个时间段肾内注射剂量的百分比与多样品清除量之间存在高度的相关性。对身体表面积的校正显著提高了相关系数。因此，建立了基于百分比剂量和体表面积的回归方程来预测多样本清除。
结论
在同一患者中进行序贯研究时，这种方法中描述的优化特征应该会提高精度。
UNLABELLED
Because commercially available camera-based methods are not optimized, they fail to account for dose infiltration, table attenuation and correspondence between time of injection and starting the camera. We have developed a more optimized technique to calculate camera-based clearances and applied this technique in the design of a camera-based clearance method for 99mTc-MAG3.
METHODS
Technetium-99m-MAG3 scintigraphy was performed in 20 patients who had varying degrees of renal function. Data were acquired posteriorly in supine patients at 2 sec/frame for 24 frames, 15 sec/frame for 16 frames and 30 sec/frame for 40 frames. Background correction was performed using an automated elliptical region of interest. Renal depth was estimated using improved regression equations and an empirically determined attenuation coefficient derived from phantom studies. Corrections were made for table attenuation and time discrepancies between dose injection and starting the camera. The percent injected dose in the kidney at 1-2, 1-2.5 and 2-3 min postinjection and the percent injected dose at those time periods corrected for body surface area were correlated with MAG3 clearance based on a single injection, two-compartment model.
RESULTS
There was high correlation between the percent injected dose in the kidney at all three time periods and the multisample clearance. Correcting for body surface areas significantly improved the correlation coefficients. Consequently, regression equations were developed to predict multisample clearance based on percent dose and body surface area.
CONCLUSION
The optimization features described in this method should improve precision when sequential studies are conducted in the same patient.
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DOI：
--
发表时间：
1986-06
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
A. Taylor;D. Eshima;A. Fritzberg;P. Christian;S. Kasina
通讯作者：
A. Taylor;D. Eshima;A. Fritzberg;P. Christian;S. Kasina
影响因子：
4.9
作者：
ESHIMA, D;TAYLOR, A
通讯作者：
TAYLOR, A
用于测量 GFR 的碘酞酸盐清除方法的比较。
影响因子：
4.1
作者：
Dowling,TC;Frye,RF;Fraley,DS;Matzke,GR
通讯作者：
Matzke,GR
从一份或两份血液样本中估算成人的 technetium-99m-MAG3 血浆清除率。
DOI：
--
发表时间：
1989
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Russell,CD;Taylor,A;Eshima,D
通讯作者：
Eshima,D