Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1.
Dissociated Deficits between Explicit and Implicit Empathetic Pain Perception in Neurofibromatosis Type 1.
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DOI：
10.3390/brainsci11121591
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发表时间：
2021-11-30
期刊：
影响因子：
3.3
通讯作者：
Liu P
中科院分区：
文献类型：
--
作者：
Xue H;Wu Q;Yang Z;Wang B;Wang X;Liu P
认知障碍和社会功能缺陷是1型神经纤维瘤病（NF 1）患者的严重主诉。由于高水平的认知缺陷，NF 1患者的移情疼痛感知可能会受到干扰。本研究探讨了成人NF 1患者的共情概况，特别是关于是否外显和内隐共情疼痛知觉在这一人群中是异常的。我们通过基于感知另一个人的疼痛的范例来检查移情疼痛感知;在这项任务中，患者被要求对疼痛的存在或身体部位的偏侧性做出判断，如图所示。20名没有明显社交或沟通困难的NF 1患者完成了这项任务，并将结果与正常对照组（NC）的结果进行了比较。关于外显移情疼痛处理，即，判断“疼痛”或“无痛”的存在，在准确性或反应时间方面，患者和对照组之间没有显著差异。然而，在内隐移情处理中，即，判断“疼痛”或“无疼痛”图片的偏侧性，NF 1患者的准确性显著低于NC患者（p = 0.038），反应时间显著高于NC患者（p = 0.004）。这些结果与先前的研究结果一致，该研究表明，在执行具有挑战性的任务时，NF 1患者的高水平认知缺陷很突出。这些缺陷背后的机制和相关的大脑网络活动应该在未来得到关注。
Cognitive impairments and social-function deficits are severe complaints in neurofibromatosis type 1 (NF1) patients. Empathetic pain perception may be disrupted in NF1 patients because of high-level cognitive deficits. This study investigated the empathy profiles of adult patients with NF1, especially concerning whether explicit and implicit empathetic pain perception are abnormal in this population. We examined empathetic pain perception through a paradigm based on perceiving another person’s pain; in this task, patients were required to make judgments about the presence of pain or the laterality of the body part, as shown in a picture. Twenty NF1 patients without obvious social or communication difficulties completed the task, and the results were compared with results from the normal controls (NCs). Regarding explicit empathetic pain processing, i.e., judging the presence of “pain” or “no pain”, there were no significant differences between patients and controls in accuracy or reaction time. However, in implicit empathetic processing, i.e., judging the laterality of “pain” or “no-pain” pictures, NF1 patients had significantly lower accuracy (p = 0.038) and significantly higher reaction times (p = 0.004) than the NCs. These results were consistent with those of a previous study showing that high-level cognitive deficits were prominent in NF1 patients when performing challenging tasks. The mechanisms and related brain network activity underlying these deficits should receive attention in the future.
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