Emotional functioning of patients with neurofibromatosis tumor suppressor syndrome.
Emotional functioning of patients with neurofibromatosis tumor suppressor syndrome.
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DOI：
10.1038/gim.2012.85
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发表时间：
2012-12
影响因子：
8.8
通讯作者：
Plotkin, Scott R.
中科院分区：
文献类型：
--
作者：
Wang, Daphne L.;Smith, Kelly B.;Esparza, Sonia;Leigh, Fawn A.;Muzikansky, Alona;Park, Elyse R.;Plotkin, Scott R.
关键词：
虽然患有神经纤维瘤病的患者易患多发性神经鞘肿瘤，这些肿瘤可以在身体的任何地方发展并导致显著的发病率（例如，听力损失;疼痛），很少有研究探讨神经纤维瘤病的情绪相关性。本研究的目的是探讨成人神经纤维瘤病患者的情绪功能。共有248例神经纤维瘤病（神经纤维瘤病1，神经纤维瘤病2或神经鞘瘤病）患者在专业诊所接受治疗，完成了有效的措施，以评估抑郁和焦虑症状，感知压力水平和自尊。与一般人群相比，神经纤维瘤病患者报告了更多的抑郁和焦虑症状，更高水平的感知压力和更低水平的自尊。在神经纤维瘤病1型、神经纤维瘤病2型和神经鞘瘤病患者中没有发现显著差异，情绪功能与疾病严重程度没有显著相关性。然而，抑郁和焦虑症状的增加，更高水平的感知压力和更低水平的自尊与过去一年自我报告的医疗访问频率较高相关（P值≤0.05）。神经纤维瘤病似乎与情绪功能下降有关。虽然还需要进一步的研究，但这些发现表明，多学科治疗方法在解决神经纤维瘤病成人患者的情绪困扰方面发挥了作用。
Although patients with neurofibromatosis are predisposed to multiple nerve sheath tumors that can develop anywhere in the body and cause significant morbidity (e.g., hearing loss; pain), little research has examined emotional correlates of neurofibromatosis. The purpose of this study was to examine emotional functioning among adult patients with neurofibromatosis. A total of 248 patients with neurofibromatosis (neurofibromatosis 1, neurofibromatosis 2, or schwannomatosis) who received care at a specialized clinic completed validated measures to assess symptoms of depression and anxiety, level of perceived stress, and self-esteem. Patients with neurofibromatosis reported significantly more symptoms of depression and anxiety, higher levels of perceived stress, and lower levels of self-esteem as compared with general population norms. No significant differences were found among patients with neurofibromatosis 1, neurofibromatosis 2, and schwannomatosis, and emotional functioning was not significantly associated with disease severity. However, increased symptoms of depression and anxiety, higher levels of perceived stress, and lower levels of self-esteem were associated with a higher frequency of self-reported medical visits in the past year (P values ≤0.05). Neurofibromatosis appears to be associated with reduced emotional functioning. Although further research is needed, these findings suggest a role for a multidisciplinary treatment approach to address emotional distress among adult patients with neurofibromatosis.
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影响因子：
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