Caloric sweetener consumption and dyslipidemia among US adults.
Caloric sweetener consumption and dyslipidemia among US adults.
复制标题
DOI：
10.1001/jama.2010.449
复制
发表时间：
2010-04-21
影响因子：
120.7
通讯作者：
Vos, Miriam B.
中科院分区：
文献类型：
--
作者：
Welsh, Jean A.;Sharma, Andrea;Abramson, Jerome L.;Vaccarino, Viola;Gillespie, Cathleen;Vos, Miriam B.
饮食中的碳水化合物与血脂异常有关，血脂异常是一种已知会增加心血管疾病风险的血脂。添加糖（在加工或制备食品中用作成分的热量甜味剂）是美国饮食中日益增加的潜在可调节成分。没有已知的研究已经检查了添加糖的消费和血脂指标之间的关联。评估美国成年人中添加糖的摄入量与血脂水平之间的关系。美国成年人（n=6113）的横断面研究，来自1999-2006年国家健康和营养调查（NHANES）。受访者根据饮食建议中规定的限制（<5% [参考组]，5%-<10%，10%-<17.5%，17.5%-<25%和≥25%的总热量）的添加糖摄入量进行分组。使用线性回归估计校正的平均脂质水平。Logistic回归分析用于确定血脂异常的校正比值比。添加糖和性别之间的相互作用进行了评估。校正的平均高密度脂蛋白胆固醇（HDL-C）、几何平均甘油三酯和平均低密度脂蛋白胆固醇（LDL-C）水平以及血脂异常（包括低HDL-C水平）的校正比值比（男性<40 mg/dL;女性<50 mg/dL）、高甘油三酯水平（≥150 mg/dL）、高LDL-C水平（≥130 mg/dL）或甘油三酯与HDL-C的高比率（>3.8）。对结果进行加权以代表美国人群。平均15.8%的卡路里来自添加糖。在摄入总能量的5%以下、5%至17.5%以下、17.5%至25%以下和25%或以上作为添加糖的参与者中，校正后的平均HDL-C水平分别为58.7、57.5、53.7、51.0和47.7 mg/dL（线性趋势P<.001），几何平均甘油三酯水平为105、102、111、113和114 mg/dL（线性趋势P<.001），女性中按性别调整的LDL-C水平为116、115、118、121和123 mg/dL（线性趋势P=.047）。男性的LDL-C水平没有显着趋势。在高消费者（≥10%添加糖）中，低HDL-C水平的几率比参考组（<5%添加糖）高50%至300%以上。在这项研究中，美国成年人的饮食添加糖和血脂水平之间存在统计学显著相关性。
Dietary carbohydrates have been associated with dyslipidemia, a lipid profile known to increase cardiovascular disease risk. Added sugars (caloric sweeteners used as ingredients in processed or prepared foods) are an increasing and potentially modifiable component in the US diet. No known studies have examined the association between the consumption of added sugars and lipid measures. To assess the association between consumption of added sugars and blood lipid levels in US adults. Cross-sectional study among US adults (n=6113) from the National Health and Nutrition Examination Survey (NHANES) 1999–2006. Respondents were grouped by intake of added sugars using limits specified in dietary recommendations (<5% [reference group], 5%–<10%, 10%–<17.5%, 17.5%–<25%, and ≥25% of total calories). Linear regression was used to estimate adjusted mean lipid levels. Logistic regression was used to determine adjusted odds ratios of dyslipidemia. Interactions between added sugars and sex were evaluated. Adjusted mean high-density lipoprotein cholesterol (HDL-C), geometric mean triglycerides, and mean low-density lipoprotein cholesterol (LDL-C) levels and adjusted odds ratios of dyslipidemia, including low HDL-C levels (<40 mg/dL for men; <50 mg/dL for women), high triglyceride levels (≥150 mg/dL), high LDL-C levels (≥130 mg/dL), or high ratio of triglycerides to HDL-C (>3.8). Results were weighted to be representative of the US population. A mean of 15.8% of consumed calories was from added sugars. Among participants consuming less than 5%, 5% to less than 17.5%, 17.5% to less than 25%, and 25% or greater of total energy as added sugars, adjusted mean HDL-C levels were, respectively, 58.7, 57.5, 53.7, 51.0, and 47.7 mg/dL (P<.001 for linear trend), geometric mean triglyceride levels were 105, 102, 111, 113, and 114 mg/dL (P<.001 for linear trend), and LDL-C levels modified by sex were 116, 115, 118, 121, and 123 mg/dL among women (P=.047 for linear trend). There were no significant trends in LDL-C levels among men. Among higher consumers (≥10% added sugars) the odds of low HDL-C levels were 50% to more than 300% greater compared with the reference group (<5% added sugars). In this study, there was a statistically significant correlation between dietary added sugars and blood lipid levels among US adults.
登录
查看更多内容
影响因子：
4.2
作者：
Montonen, Jukka;Jarvinen, Ritva;Reunanen, Antti
通讯作者：
Reunanen, Antti
影响因子：
37.8
作者：
CARLETON, RA;DWYER, J;STOKES, J
通讯作者：
STOKES, J
影响因子：
4.7
作者：
Krebs-Smith, SM;Graubard, BI;Ballard-Barbash, R
通讯作者：
Ballard-Barbash, R
影响因子：
37.8
作者：
Grundy, SM;Becker, D;Jehle, AJ
通讯作者：
Jehle, AJ
DOI：
10.14219/jada.archive.2007.0019
发表时间：
2007-01-01
影响因子：
3.9
作者：
Marshall, Teresa A.;Eichenberger-Gilmore, Julie M.;Levy, Steven M.
通讯作者：
Levy, Steven M.