Mutation of protein kinase A causes heterochronic development of Dictyostelium
Mutation of protein kinase A causes heterochronic development of Dictyostelium
复制标题
蛋白激酶A突变导致盘基网柄菌异时发育
作者：
M. Simon;Olivier Pelegrini;M. Véron;R. Kay
在异时突变体中，与野生型相比，发育事件的相对时间发生了改变。这通常会导致胚胎紊乱1，2，但异时突变也可能是进化变异的重要来源3。在快速发展的（rde）突变体的网柄藻，柄和孢子细胞分化之前，形态建成完成。我们已经追踪到一类这些突变体的环腺苷酸依赖性蛋白激酶（PK-A）的调节亚基的病变。这种蛋白质的失活导致催化亚基的活性不受限制，从而过早地触发终末细胞分化。
IN heterochronic mutants the relative timing of developmental events is altered compared with the wild type. This generally results in a disordered embryo1,2, though heterochronic mutations may also be an important source of evolutionary variation3. In the rapidly developing (rde) mutants of Dictyostelium, stalk and spore cells differentiate before morphogenesis is complete. We have traced the lesion in one class of these mutants to the regulatory subunit of cyclic AMP-dependent protein kinase (pk-A). Inactivation of this protein results in the unrestrained activity of the catalytic subunit, so prematurely triggering terminal cell differentiation.
影响因子：
56.9
作者：
AMBROS, V;HORVITZ, HR
通讯作者：
HORVITZ, HR
影响因子：
56.9
作者：
KNIGHTON, DR;ZHENG, JH;SOWADSKI, JM
通讯作者：
SOWADSKI, JM