Motor training in degenerative spinocerebellar disease: ataxia-specific improvements by intensive physiotherapy and exergames.
Motor training in degenerative spinocerebellar disease: ataxia-specific improvements by intensive physiotherapy and exergames.
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DOI：
10.1155/2014/583507
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发表时间：
2014
影响因子：
--
通讯作者：
Ilg W
中科院分区：
文献类型：
--
作者：
Synofzik M;Ilg W
小脑基本上参与运动控制，并在运动学习中发挥关键作用。退化性小脑疾病患者是否能从高强度的协调训练中获益一直存在争议。此外，目前尚不清楚这些患者通过哪些训练方法和机制可以改善他们的运动表现。在这里，我们回顾了来自退行性脊髓小脑疾病患者不同高强度训练研究的证据。这些研究表明，高强度的协调训练可能会导致退行性共济失调患者的显着利益。这种训练可能基于物理疗法或全身控制的视频游戏（“exergames”）。这些研究中显示的益处等于恢复一年或多年的自然疾病进展。此外，第一个案例研究表明，即使是患有晚期神经退行性疾病的受试者也可能从这种训练计划中受益。对于这两种类型的训练，观察到的临床改善被共济失调特异性功能障碍的恢复所掩盖（例如，多关节协调和动态稳定性）。重要的是，对于这两种类型的训练，效果的保持似乎取决于训练的频率和连续性。基于这些研究，我们在这里提出了临床实践的初步建议，并阐明开放的问题，可能会指导未来的研究神经康复退行性脊髓小脑疾病。
The cerebellum is essentially involved in movement control and plays a critical role in motor learning. It has remained controversial whether patients with degenerative cerebellar disease benefit from high-intensity coordinative training. Moreover, it remains unclear by which training methods and mechanisms these patients might improve their motor performance. Here, we review evidence from different high-intensity training studies in patients with degenerative spinocerebellar disease. These studies demonstrate that high-intensity coordinative training might lead to a significant benefit in patients with degenerative ataxia. This training might be based either on physiotherapy or on whole-body controlled videogames (“exergames”). The benefit shown in these studies is equal to regaining one or more years of natural disease progression. In addition, first case studies indicate that even subjects with advanced neurodegeneration might benefit from such training programs. For both types of training, the observed clinical improvements are paralleled by recoveries in ataxia-specific dysfunctions (e.g., multijoint coordination and dynamic stability). Importantly, for both types of training, the retention of the effects seems to depend on the frequency and continuity of training. Based on these studies, we here present preliminary recommendations for clinical practice, and articulate open questions that might guide future studies on neurorehabilitation in degenerative spinocerebellar disease.
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影响因子：
9.9
作者：
Jacobi, H.;Bauer, P.;Klockgether, T.
通讯作者：
Klockgether, T.
DOI：
10.1126/science.1212673
发表时间：
2011-11-04
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
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通讯作者：
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影响因子：
8.6
作者：
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通讯作者：
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影响因子：
5.7
作者：
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