Long-term safety, tolerability, and efficacy of magnesium valproate versus sodium valproate in acute seizures
Long-term safety, tolerability, and efficacy of magnesium valproate versus sodium valproate in acute seizures
复制标题
丙戊酸镁与丙戊酸钠治疗急性癫痫发作的长期安全性、耐受性和疗效
DOI：
10.1080/03007995.2019.1699520
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发表时间：
2019-11
影响因子：
2.3
通讯作者：
Xin Xu
中科院分区：
文献类型：
--
作者：
Xiaoyan Peng;Yin Yan;Rui Chen;Xuefeng Wang;Xin Xu
目的：评价丙戊酸镁和丙戊酸钠单药治疗癫痫病人的安全性、耐受性和疗效。方法：我们招募了住院两年以上的癫痫发作患者。所有患者均进行了早期神经学评估、脑电图检查和神经影像学检查。比较基线和1年随访时的治疗情况。结果：共纳入175例患者。丙戊酸镁处理和丙戊酸钠处理的保留率分别为73.1%和64.2%。停药的主要原因是发生了无法忍受的不良事件。丙戊酸镁组的滞留率和总有效率分别为73.1%和70.2%，显著高于丙戊酸钠组（分别为64.2%和47.2%）。安全性终点包括120例患者（丙戊酸镁：n = 67；丙戊酸钠：n = 53）。丙戊酸镁组的不良事件发生率明显低于丙戊酸钠组（30% vs 51%）。结论：丙戊酸镁治疗具有良好的安全性和耐受性，并可显著改善癫痫发作控制。理想情况下，未来需要进行大型、前瞻性、随机和双盲研究来证实这些发现。
Abstract Objectives: To evaluate the safety, tolerability and efficacy of magnesium valproate and sodium valproate as monotherapies in patients with epilepsy in China. Methods: We recruited patients admitted with seizures over a two-year period. All patients underwent early neurological assessments, electroencephalogram testing, and neuroimaging. The treatments received at baseline and at one year of follow-up were compared. Results: In total, 175 patients were included. The retention rates of the magnesium valproate and sodium valproate treatments were 73.1% and 64.2%, respectively. The main cause of discontinuation was the development of intolerable adverse events. The retention rate and total effective rate in the magnesium valproate group were significantly higher than those in the sodium valproate group (73.1% and 70.2% versus 64.2% and 47.2%, respectively). The safety endpoints included 120 patients (magnesium valproate: n = 67; sodium valproate: n = 53). The incidence of adverse events in the magnesium valproate group was significantly lower than that in the sodium valproate group (30% versus 51%). Conclusions: Magnesium valproate treatment shows favorable safety and tolerability and is associated with markedly improved seizure control. Ideally, future large, prospective, randomized, and double-blind studies are needed to confirm these findings.
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影响因子：
3.8
作者：
Dharnidharka, VR;Carney, PR
通讯作者：
Carney, PR
影响因子：
5.1
作者：
Xin Xu;Yida Hu;Y. Xiong;Zhonggui Li;Wei Wang;Chao Du;Yong Yang;Yanke Zhang;F. Xiao;Xuefeng Wang
通讯作者：
Xin Xu;Yida Hu;Y. Xiong;Zhonggui Li;Wei Wang;Chao Du;Yong Yang;Yanke Zhang;F. Xiao;Xuefeng Wang
DOI：
--
发表时间：
2014-11
期刊：
Austin journal of nutrition and food sciences
影响因子：
--
作者：
Samantha Long;A. Romani
通讯作者：
Samantha Long;A. Romani
DOI：
10.1016/j.seizure.2015.09.017
发表时间：
2015-11
期刊：
Seizure
影响因子：
--
作者：
Frederick A. Zeiler;M. Matuszczak;Jeanne Teitelbaum;L. Gillman;C. Kazina
通讯作者：
Frederick A. Zeiler;M. Matuszczak;Jeanne Teitelbaum;L. Gillman;C. Kazina
影响因子：
2.9
作者：
CZEH, G;SOMJEN, GG
通讯作者：
SOMJEN, GG