The Swedish childhood diabetes study — results from a nine year case register and a one year case-referent study indicating that Type 1 (insulin-dependent) diabetes mellitus is associated with both Type 2 (non-insulin-dependent) diabetes mellitus and autoimmune disorders
The Swedish childhood diabetes study — results from a nine year case register and a one year case-referent study indicating that Type 1 (insulin-dependent) diabetes mellitus is associated with both Type 2 (non-insulin-dependent) diabetes mellitus and autoimmune disorders
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瑞典儿童糖尿病研究——九年病例登记和一年病例参考研究的结果表明，1 型（胰岛素依赖型）糖尿病与 2 型（非胰岛素依赖型）糖尿病和自身免疫性疾病相关
作者：
G. Dahlquist;L. Blom;T. Tuvemo;L. Nyström;A. Sandström;Stig Wall
从1977年7月1日到1986年7月1日，瑞典儿童糖尿病研究登记了3503例1型(胰岛素依赖型)糖尿病病例。使用这一登记和病例参照研究的数据，包括瑞典一年内发生的所有1型糖尿病儿童，以及每个患者的两名参照儿童(按年龄、性别和县匹配)，我们研究了1型糖尿病与家族性1型和2型(非胰岛素依赖型)糖尿病、甲状腺、肾上腺、过敏性、风湿性、心脏病和肠道疾病的关系。在这九年期间，平均每10万人中的年发病率男孩为25.1，女孩为23.5。在8.5%的患者中，父母一方患有1型糖尿病，其中73%是父亲。56名患者(1.7%)的父母患有2型糖尿病。父母1型糖尿病的患病率往往在发病年龄较小的患者中更高；而在父母患有2型糖尿病的患者中则相反。在病例参考研究中，当第一和/或第二级亲属患有1型糖尿病时，年龄调整后的1型糖尿病的优势比为5.5(95%可信区间为4.0-7.7)，根据病例登记的结果，发病年龄最小的患者的优势比往往最高。患者发病的季节与父母的1型糖尿病无关。当亲属(三代)报告有2型糖尿病时，1型糖尿病的优势比显著增加3.3(95%可信限：2.3-4.6)。当亲属中有甲状腺或风湿性疾病时，优势比也显著增加(p(0.05)。结论：虽然大多数发病的1型糖尿病儿童没有家族史，但父母1型糖尿病可能影响发病年龄，但对这些儿童的性别分布没有影响。当亲属报告患有2型糖尿病、(未经胰岛素治疗的)甲状腺疾病或风湿病时，儿童患1型糖尿病的风险也会增加。
SummaryFrom July 1, 1977 to July 1, 1986, 3,503 incident cases of Type 1 (insulin-dependent) diabetes mellitus were registered in the Swedish childhood diabetes study. Using data from this register and from a case-referent study, including all incident Type 1 diabetic children in Sweden during one year and, for each patient, two referent children matched according to age, sex and county, we have studied the associations between Type 1 diabetes and familial Type 1 and Type 2 (non-insulin-dependent) diabetes, thyroid, adrenal, allergic, rheumatic, heart and bowel disease. The mean annual incidence per 100,000 during the nine year period was 25.1 for boys and 23.5 for girls. In 8.5% of the patients, one parent had Type 1 diabetes, 73% of whom were fathers. Fifty-six of the patients (1.7%) had a parent with Type 2 diabetes. The prevalence of parental Type 1 diabetes tended to be higher in patients with younger age at onset; whereas, the opposite was found for patients with parental Type 2 diabetes. In the case-referent study, the age-adjusted odds ratio for Type 1 diabetes when a first and/or second degree relative had Type 1 diabetes was 5.5 (95% confidence limits 4.0–7.7), and in accordance with the findings of the case register, the odds ratio tended to be highest in patients with the youngest age at onset. Season at onset of the patients was not associated with parental Type 1 diabetes. The odds ratio for Type 1 diabetes was significantly increased 3.3 (95% confidence limits: 2.3–4.6) when Type 2 diabetes was reported in relatives (three generations). Odds ratios were also significantly increased (p(0.05) when thyroid or rheumatic diseases were reported among relatives.It is concluded that although the majority of incident Type 1 diabetic children lack family history, parental Type 1 diabetes may influence the age at onset of the disease but has no effect on sex distribution of these children. An increased risk for Type 1 diabetes in children is also indicated when Type 2 diabetes, (non-insulin-treated) thyroid or rheumatic disease is reported in relatives.
胰岛素依赖型糖尿病患者亲属的 B 细胞功能以及胰岛细胞和其他器官特异性自身抗体。
影响因子：
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作者：
Nordén,G;Jensen,E;Stilbo,I;Bottazzo,GF;Lernmark,A
通讯作者：
Lernmark,A