Yoga for persistent fatigue in breast cancer survivors: a randomized controlled trial.
Yoga for persistent fatigue in breast cancer survivors: a randomized controlled trial.
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DOI：
10.1002/cncr.26702
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发表时间：
2012-08-01
期刊：
影响因子：
6.2
通讯作者：
Greendale G
中科院分区：
文献类型：
--
作者：
Bower JE;Garet D;Sternlieb B;Ganz PA;Irwin MR;Olmstead R;Greendale G
与癌症相关的疲劳困扰着多达三分之一的乳腺癌幸存者，但目前还没有经验证的治疗方法来治疗这种症状。我们进行了两组随机对照试验，以确定艾扬格瑜伽干预对患有持续性治疗后疲劳的乳腺癌幸存者的可行性和有效性。参与者是乳腺癌患者，他们在登记前至少6个月完成了癌症治疗(内分泌治疗除外)，报告了严重的癌症相关疲劳，并且没有其他会导致疲劳症状或干扰瑜伽练习的医疗条件。采用随机分组的方法，将参与者分配到为期12周的基于艾扬格的瑜伽干预或为期12周的健康教育(对照)。主要结果是在基线、治疗后即刻和治疗完成后3个月测量的疲劳度的变化。其他结果包括活力、抑郁症状、睡眠、感觉到的压力和身体表现的变化。使用线性混合模型对所有随机参与者进行意向处理分析。31名女性被随机分配到瑜伽组(n=16)或健康教育组(n=15)。与对照组相比，瑜伽组的疲劳严重程度从基线到治疗后以及超过3个月的随访都显著下降(P=.032)。此外，瑜伽组的活力显著高于对照组(P=.011)。两组患者在抑郁症状和感受到的压力方面均有积极的变化(P<；0.05)。没有观察到睡眠或体能方面的显著变化。有针对性的瑜伽干预显著改善了持续疲劳症状的乳腺癌幸存者的疲劳和活力。
Cancer-related fatigue afflicts up to one-third of breast cancer survivors, yet there are no empirically-validated treatments for this symptom. We performed a two-group RCT to determine the feasibility and efficacy of an Iyengar yoga intervention for breast cancer survivors with persistent post-treatment fatigue. Participants were breast cancer patients who had completed cancer treatments (other than endocrine therapy) at least 6 months prior to enrollment, reported significant cancer-related fatigue, and had no other medical conditions that would account for fatigue symptoms or interfere with yoga practice. Block randomization was used to assign participants to a 12-week Iyengar-based yoga intervention or to 12 weeks of health education (control). The primary outcome was change in fatigue measured at baseline, immediately post-treatment, and 3 months after treatment completion. Additional outcomes included changes in vigor, depressive symptoms, sleep, perceived stress, and physical performance. Intent to treat analyses were conducted with all randomized participants using linear mixed models. Thirty-one women were randomly assigned to yoga (n = 16) or health education (n = 15). Fatigue severity declined significantly from baseline to post-treatment and over a 3 month follow-up in the yoga group relative to controls (P = .032). In addition, the yoga group showed significant increases in vigor relative to controls (P = .011). Both groups showed positive changes in depressive symptoms and perceived stress (P < .05). No significant changes in sleep or physical performance were observed. A targeted yoga intervention led to significant improvements in fatigue and vigor among breast cancer survivors with persistent fatigue symptoms.
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DOI：
10.1111/j.1745-7599.2010.00573.x
发表时间：
2011-03-01
影响因子：
--
作者：
Banasik, Jacquelyn;Williams, Holly;Bendel, Robert
通讯作者：
Bendel, Robert
影响因子：
3.3
作者：
Bower, JE;Ganz, PA;Aziz, N
通讯作者：
Aziz, N
影响因子：
3.8
作者：
Courneya, KS;Friedenreich, CM;Fairey, AS
通讯作者：
Fairey, AS
影响因子：
10.3
作者：
Bower, JE;Ganz, PA;Cole, SW
通讯作者：
Cole, SW
影响因子：
3.6
作者：
Culos-Reed, S. Nicole;Carlson, Linda E.;Hately-Aldous, Susi
通讯作者：
Hately-Aldous, Susi