Human herpesvirus 6 infection as a trigger of multiple sclerosis.
Human herpesvirus 6 infection as a trigger of multiple sclerosis.
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人类疱疹病毒 6 感染可引发多发性硬化症。
DOI：
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发表时间：
2010
影响因子：
8.9
通讯作者：
E. Stamboulis
中科院分区：
文献类型：
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作者：
K. Voumvourakis;D. Kitsos;S. Tsiodras;G. Petrikkos;E. Stamboulis
我们系统地回顾了现有的证据，以确定感染人类疱疹病毒6 （HHV-6）与多发性硬化症（MS）之间是否存在关系，如果存在，则确定这种关系的强度。检索Entrez-PubMed数据库（1966-2009）时使用了以下术语：人类疱疹病毒6型、HHV 6型、脱髓鞘、多发性硬化症、发病机制、诊断、血清学、脑脊液、IgG抗体、IgM抗体、PCR和淋巴细胞增殖技术。采用Moore和Wolfson提出的标准和加拿大定期健康检查工作组使用的分类标准对研究质量进行评估。根据Moore和Wolfson标准，根据实验技术和质量（高[A]，中级[B]和低[C]）对研究进行分类。总体而言，61项研究中有25项（41%）达到了统计学显著的结果，其中15项（60%）为A质量。根据加拿大特别工作组的分类，所有研究都被归类为质量II-1的证据。讨论了现有实验技术的局限性和未来研究的前景。目前的综述支持需要进一步、客观、基于证据的HHV-6感染与多发性硬化症之间关系的检查。
We systematically reviewed the existing evidence to determine whether a relationship exists between infection with human herpesvirus 6 (HHV-6) and multiple sclerosis (MS) and, if so, to define the strength of that relationship. The following terms were used in searches of the Entrez-PubMed database (1966-2009): human herpes virus 6, HHV 6, demyelination, multiple sclerosis, pathogenesis, diagnosis, serology, cerebrospinal fluid, IgG antibodies, IgM antibodies, PCR, and lymphoproliferative techniques. Study quality was assessed using the criteria proposed by Moore and Wolfson and by the classification criteria used by the Canadian Task Force on the Periodic Health Examination. Studies were categorized both by experimental technique and by quality (high [A], intermediate [B], and low [C]) as determined by the Moore and Wolfson criteria. Overall, 25 (41%) of 61 studies, 15 (60%) of which were classified as A quality, reached a statistically significant result. According to the Canadian Task Force classification, all studies were categorized as evidence of quality II-1. Limitations of the available experimental techniques and perspectives for future research are discussed. The current review supports the need for further, objective, evidence-based examination of the relationship between HHV-6 infection and multiple sclerosis.
慢性疲劳综合征患者体内针对人类疱疹病毒 6 早期抗原 (p41/38) 的 IgM 抗体的流行情况。
DOI：
10.1093/infdis/172.5.1364
发表时间：
1995
期刊：
The Journal of infectious diseases
影响因子：
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作者：
Patnaik,M;Komaroff,AL;Conley,E;Ojo-Amaize,EA;Peter,JB
通讯作者：
Peter,JB