Reduction in regional cerebral metabolic rate of oxygen during human aging.
Reduction in regional cerebral metabolic rate of oxygen during human aging.
复制标题
人类衰老过程中局部脑氧代谢率降低。
作者：
Tatsuo Yamaguchi
为探讨脑循环和氧代谢在增龄过程中的变化，应用~（15）O标记气体吸入技术和多层正电子发射断层扫描仪（PET）测定了22名健康志愿者的局部脑血流量（rCBF）、局部氧摄取分数（rOEF）、局部脑氧代谢率（rCMRO_2）和局部脑血容量（rCBV）。年龄介乎26至64岁。这些测量是在受试者休息时进行的，没有感觉剥夺。在使用与PET对应的X射线计算机断层扫描图像对功能PET图像进行解剖学识别后，通过研究每个感兴趣区域的大系列扫描，评价了超过40个脑解剖结构中的rCBF、rOEF、rCMRO 2和rCBV值。在平均灰度值中，只有CMRO 2显示出随年龄增长而显著降低。rCMRO 2仅在幕上随年龄增长而显著降低，而在左半球下降更多。尤其显著的是左侧尾状核区域的rCMRO 2减少。CBF和OEF都是可变的，年龄依赖性较小。结论是CMRO 2可以最适当地反映健康的大脑老化。
To investigate changes in cerebral circulation and oxygen metabolism during aging, regional cerebral blood flow (rCBF), regional oxygen extraction fraction (rOEF), regional cerebral metabolic rate of oxygen (rCMRO2) and regional cerebral blood volume (rCBV) were measured using the 15O labelled gas inhalation technique and a multi-slice positron emission tomograph (PET) in 22 healthy volunteers, aged from 26 to 64 years old. The measurements were performed with subjects at rest, without sensory deprivation. The values of rCBF, rOEF, rCMRO2 and rCBV in more than 40 anatomical structures of the brain were evaluated by studying a large series of scans in each region of interest after the functional PET image had been anatomically identified using x-ray computed tomographic images corresponding to the PET. In mean gray values, only CMRO2 showed significant reduction with age. rCMRO2 significantly decreased with age only in the supratentrium, and much more in the left hemisphere. Especially remarkable was rCMRO2 reduction in the left caudate region. Both CBF and OEF were variable and less age-dependent. It was concluded that CMRO2 could be reflecting healthy brain aging most properly.
阿司匹林抑制血管成形术部位的血小板沉积：血小板闪烁扫描证实。
影响因子：
19.7
作者：
Cunningham,DA;Kumar,B;Siegel,BA;Gilula,LA;Totty,WG;Welch,MJ
通讯作者：
Welch,MJ