Ubiquitin in retrovirus assembly: actor or bystander?
Ubiquitin in retrovirus assembly: actor or bystander?
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逆转录病毒组装中的泛素：演员还是旁观者？
DOI：
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发表时间：
2000
影响因子：
11.1
通讯作者：
V. Vogt
中科院分区：
文献类型：
--
作者：
V. Vogt
逆转录病毒的装配看似简单。病毒样颗粒的形成仅需要gag基因的产物（1）。在细胞质中合成后，Gag被靶向质膜，其中Gag-Gag相互作用、Gag-RNA相互作用、Gag-膜相互作用以及可能的Gag-宿主蛋白相互作用导致新生病毒颗粒向外凸出，首先为马蹄形，然后为棒棒糖形结构，其可以通过电子显微镜观察到。病毒的膜扩张过程称为出芽。出芽的最后一步是膜融合事件，用于夹断病毒，将其释放到培养基中。在装配后期，可能伴随着夹断或就在夹断之前，病毒蛋白酶在几个位点切割Gag，导致病毒的形态变化。这个过程被称为成熟，是病毒变得具有传染性所必需的。
The assembly of retroviruses is deceptively simple. Only the product of the gag gene is required for the formation of a virus-like particle (1). After its synthesis in the cytoplasm Gag is targeted to the plasma membrane, where Gag-Gag interactions, Gag-RNA interactions, Gag-membrane interactions, and perhaps Gag-host protein interactions lead to a bulging out of the nascent virus particle, first as a horseshoe-shaped and then as a lollipop-shaped structure that can be visualized by electron microscopy. The process of membrane envelopment of the virus is called budding. The last step in budding is a membrane fusion event that serves to pinch off the virus, releasing it into the medium. Late in assembly, perhaps concomitant with pinching off or just preceding it, a viral protease cleaves Gag at several sites, leading to a morphological change in the virus. This process is called maturation and is essential for the virus to become infectious.
DOI：
10.1073/pnas.97.24.13057
发表时间：
2000-11-21
影响因子：
11.1
作者：
Schubert, U;Ott, DE;Yewdell, JW
通讯作者：
Yewdell, JW
DOI：
10.1073/pnas.88.8.3195
发表时间：
1991-04-01
影响因子：
11.1
作者：
GOTTLINGER, HG;DORFMAN, T;HASELTINE, WA
通讯作者：
HASELTINE, WA