Adiponectin exacerbates collagen-induced arthritis via enhancing Th17 response and prompting RANKL expression.
Adiponectin exacerbates collagen-induced arthritis via enhancing Th17 response and prompting RANKL expression.
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脂联素通过增强 Th17 反应和促进 RANKL 表达加剧胶原诱导的关节炎
DOI：
10.1038/srep11296
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发表时间：
2015-06-11
影响因子：
4.6
通讯作者：
Zhang M
中科院分区：
文献类型：
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作者：
Sun X;Feng X;Tan W;Lin N;Hua M;Wei Y;Wang F;Li N;Zhang M
我们先前报道脂联素(AD)在炎症的滑膜关节组织中高表达，并与类风湿关节炎(RA)患者进行性骨侵蚀密切相关。在此，我们通过第一次胶原免疫后第17天、第20天和第23天膝关节内注射脂联素来研究脂联素对CIA小鼠Th17反应和核因子受体激活剂-κB配体(RANKL)表达的调节作用。在胶原性关节炎(CIA)小鼠的炎症关节组织中，脂联素的表达增加。注射脂联素可使CIA小鼠关节炎发病时间提前，关节炎进展加重，滑膜增生加重，骨质侵蚀和骨质疏松。脂联素处理的CIA小鼠关节组织中CD_4+IL-17+Th17细胞、IL-17 RANKL 和RANKL mRNA的表达显著增加。脂联素可显著促进体外培养的初始CD_4~+T细胞产生Th17细胞，并伴随Th17转录因子RoR-γt和IL-22、IL-23等Th17细胞因子基因的高表达。这项研究揭示了脂联素通过增强Th17细胞反应和RANKL表达来加速CIA进展的新作用。
We previously reported adiponectin (AD) is highly expressed in the inflamed synovial joint tissue and correlates closely with progressive bone erosion in Rheumatoid arthritis (RA) patients. Here, we investigate the role of adiponectin in regulating Th17 response and the expression of receptor activator of nuclear factor-κB ligand (RANKL) in mice with CIA mice by intraarticularly injection of adiponectin into knee joints on day 17, day 20 and day 23 post first collagen immunization. The increased adiponectin expression was found in inflamed joint tissue of collagen-induced arthritis (CIA) mice. Adiponectin injection resulted in an earlier onset of arthritis, an aggravated arthritic progression, more severe synovial hyperplasia, bone erosion and osteoporosis in CIA mice. CD4+IL-17+Th17 cells, IL-17 mRNA and RANKL mRNA expression were markedly increased in the joint tissue of adiponectin treated CIA mice. Moreover, adiponectin treatment markedly enhanced Th17 cell generation from naive CD4+T cellsin vitro, which accompanied by the high expression of Th17 transcription factor ROR-γt and Th17 cytokine genes included IL-22 and IL-23. This study reveals a novel effect of adiponectin in exacerbating CIA progression by enhancing Th17 cell response and RANKL expression.
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影响因子：
64.5
作者：
Ivanov, Ivaylo I.;McKenzie, Brent S.;Littman, Dan R.
通讯作者：
Littman, Dan R.
影响因子：
4.9
作者：
Adamopoulos IE;Chao CC;Geissler R;Laface D;Blumenschein W;Iwakura Y;McClanahan T;Bowman EP
通讯作者：
Bowman EP
影响因子：
--
作者：
Kim, Kyoung-Woon;Kim, Hae-Rim;Lee, Sang-Heon
通讯作者：
Lee, Sang-Heon
影响因子：
2.1
作者：
Lee, S-W;Kim, J-H;Lee, S-K
通讯作者：
Lee, S-K
DOI：
10.1038/nrrheum.2012.153
发表时间：
2012-11
期刊：
Nature reviews. Rheumatology
影响因子：
--
作者：
通讯作者：
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