Prognostic value from integrative analysis of transcription factors c-Jun and Fra-1 in oral squamous cell carcinoma: a multicenter cohort study.
Prognostic value from integrative analysis of transcription factors c-Jun and Fra-1 in oral squamous cell carcinoma: a multicenter cohort study.
复制标题
口腔鳞状细胞癌转录因子 c-Jun 和 Fra-1 综合分析的预后价值：多中心队列研究
DOI：
10.1038/s41598-017-05106-5
复制
发表时间：
2017-08-08
影响因子：
4.6
通讯作者：
Chen QM
中科院分区：
文献类型：
--
作者：
Xu H;Jin X;Yuan Y;Deng P;Jiang L;Zeng X;Li XS;Wang ZY;Chen QM
据报道，转录因子 c-Jun 和 Fra-1 在口腔鳞状细胞癌 (OSCC) 的发生和进展过程中发挥作用。然而，队列研究却鲜有报道。以下是通过多中心队列研究对其在 OSCC 中的预后价值进行的综合分析。本研究纳入了 313 名 OSCC 患者并接受定期随访。通过生存分析产生生存率和风险比（HR）。选择一致性概率和受试者工作特征曲线面积来衡量模型辨别力。 c-Jun或Fra-1高表达与预后不良相关，同时Fra-1高表达比c-Jun高表达意味着患者预后更差。此外，c-Jun和Fra-1的相互作用呈拮抗作用，当c-Jun和Fra-1均高表达时，HR低于仅Fra-1高表达时的风险比。 c-Jun和Fra-1均被证明是OSCC死亡的高风险预测因子，拮抗作用表明这些生物标志物的活性可能相互影响。这可能为OSCC预后和治疗的研究提供新的视角。
Transcription factors c-Jun and Fra-1 have been reported to play a role during the initiation and progression in oral squamous cell carcinoma (OSCC). However, cohort studies are rarely reported. Here is an integrative analysis of their prognostic value in OSCC through a multicenter cohort study.313 OSCC patients were included in this study and received regular follow-up. The survival rate and hazard ratios(HR) were generated by survival analysis. The concordance probability and receiver operating characteristic curve area were chosen to measure the model discrimination. High expressions of c-Jun or Fra-1 were associated with poor prognosis, meanwhile the high expression of Fra-1 meant worse prognosis of patients than the high expression of c-Jun. Besides, the interaction effect of c-Jun and Fra-1 was antagonism, when the expression of c-Jun and Fra-1 was both high, theHRwas lower than the hazard ratio when only the Fra-1 was at high expression. c-Jun and Fra-1 were both proved to be high risky predictors of death in OSCC, the antagonistic effect suggested that these biomarkers’ activities could be influenced by each other. It may provide a new sight for the studies of OSCC prognosis and treatment.
登录
查看更多内容
影响因子：
4
作者：
Hess, J;Angel, P;Schorpp-Kistner, M
通讯作者：
Schorpp-Kistner, M
影响因子：
5.6
作者：
Chuang JY;Huang YL;Yen WL;Chiang IP;Tsai MH;Tang CH
通讯作者：
Tang CH
影响因子：
6.6
作者：
Leelahavanichkul, Kantima;Amornphimoltham, Panomwat;Molinolo, Alfredo A.;Basile, John R.;Koontongkaew, Sittichai;Gutkind, J. Silvio
通讯作者：
Gutkind, J. Silvio
蛋白酶体激活剂 PA28γ 与口腔鳞状细胞癌结果之间的关联：来自队列研究和功能分析的证据。
影响因子：
11.1
作者：
Li J;Feng X;Sun C;Zeng X;Xie L;Xu H;Li T;Wang R;Xu X;Zhou X;Zhou M;Zhou Y;Dan H;Wang Z;Ji N;Deng P;Liao G;Geng N;Wang Y;Zhang D;Lin Y;Ye L;Liang X;Li L;Luo G;Jiang L;Wang Z;Chen Q
通讯作者：
Chen Q
EGF诱导的头颈癌细胞转移中的PTX3基因激活。
影响因子：
--
作者：
Chang WC;Wu SL;Huang WC;Hsu JY;Chan SH;Wang JM;Tsai JP;Chen BK
通讯作者：
Chen BK