Polymeric carriers: role of geometry in drug delivery.
Polymeric carriers: role of geometry in drug delivery.
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DOI：
10.1517/17425240802567846
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发表时间：
2008-12
影响因子：
6.6
通讯作者：
Muzykantov VR
中科院分区：
文献类型：
--
作者：
Simone EA;Dziubla TD;Muzykantov VR
人工合成纳米结构具有独特的性质，在生物相容性、药物动力学、靶向性和药物控制释放等方面具有良好的应用前景，可广泛应用于药物载体的研究。从历史上看，更传统的药物输送系统一直专注于球形载体。然而，由于新的配方策略，人们对追求非球形载体越来越感兴趣，例如细长或丝状的形态。这些超分子结构独特的物理化学性质为药物输送系统提供了独特的优势。特别是，最近对细胞培养和实验动物的研究结果表明，合理设计给定几何形状的载体可以前所未有地控制它们在循环中的寿命，并针对选定的细胞和亚细胞位置。本文综述了非球形给药系统的材料选择与处方、载药与释放、生物相容性、循环行为、靶向性及亚细胞寻址等方面的研究进展。
The unique properties of synthetic nanostructures promise a diverse set of applications as carriers for drug delivery, which are advantageous in terms of biocompatibility, pharmacokinetics, targeting and controlled drug release. Historically, more traditional drug delivery systems have focused on spherical carriers. However, there is a growing interest in pursuing non-spherical carriers, such as elongated or filamentous morphologies, now available due to novel formulation strategies. Unique physiochemical properties of these supramolecular structures offer distinct advantages as drug delivery systems. In particular, results of recent studies in cell cultures and lab animals indicate that rational design of carriers of a given geometry (size and shape) offers an unprecedented control of their longevity in circulation and targeting to selected cellular and subcellular locations. This article reviews drug delivery aspects of non-spherical drug delivery systems, including material selection and formulation, drug loading and release, biocompatibility, circulation behavior, targeting and subcellular addressing.
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影响因子：
10.8
作者：
Dziubla, TD;Karim, A;Muzykantov, VR
通讯作者：
Muzykantov, VR
影响因子：
10.8
作者：
Champion, Julie A.;Katare, Yogesh K.;Mitragotri, Samir
通讯作者：
Mitragotri, Samir
影响因子：
3.4
作者：
Accardo, Antonella;Tesauro, Diego;Morelli, Giancarlo
通讯作者：
Morelli, Giancarlo
影响因子：
10.8
作者：
Garnacho, Carmen;Albelda, Steven M.;Muro, Silvia
通讯作者：
Muro, Silvia
影响因子：
--
作者：
Cato, Matthew H.;D'Annibale, Federica;Bottini, Massimo
通讯作者：
Bottini, Massimo