Association Between Human Leukocyte Antigen Class I and II Diversity and Non-virus-associated Solid Tumors.
Association Between Human Leukocyte Antigen Class I and II Diversity and Non-virus-associated Solid Tumors.
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DOI：
10.3389/fgene.2021.675860
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发表时间：
2021
影响因子：
3.7
通讯作者：
Hildesheim A
中科院分区：
文献类型：
--
作者：
Liu Z;Hildesheim A
人类白细胞抗原（HLA）基因座的纯合性可能会导致免疫监视功能降低和疾病风险增加，包括由感染或造血来源引起的癌症。为了研究HLA接合性与非病毒相关实体瘤风险之间的关联，我们利用了来自28，000多名欧洲血统个体的全基因组关联研究（GWAS）数据，这些个体参与了12个癌症部位（膀胱，脑，乳腺，结肠，子宫内膜，肾，肺，卵巢，胰腺，前列腺，皮肤和睾丸）的研究。通过插补获得HLA接合性信息;当插补携带相同的四位数等位基因时，个体被归类为给定基因座的纯合子。我们没有观察到6个HLA基因座的接合性与所有癌症相关联的证据。HLA I类基因座、II类基因座或I类和II类基因座纯合子数量的增加也与总体癌症无关（Ptrend = 0.28），每个基因座风险的调整后比值比（OR）为1.00 [95%置信区间（CI）= 0.97，1.03]，1.02（0.99，1.04）和1.01（0.99，1.02）。这项研究并不支持HLA接合性对非病毒相关实体瘤风险的重要作用。
Homozygosity at human leukocyte antigen (HLA) loci might lead to reduced immunosurveillance and increased disease risk, including cancers caused by infection or of hematopoietic origin. To investigate the association between HLA zygosity and risk of non-virus-associated solid tumors, we leveraged genome-wide association study (GWAS) data from over 28,000 individuals of European ancestry who participated in studies of 12 cancer sites (bladder, brain, breast, colon, endometrial, kidney, lung, ovary, pancreas, prostate, skin, and testis). Information on HLA zygosity was obtained by imputation; individuals were classified as homozygotes at a given locus when imputed to carry the same four-digit allele at that locus. We observed no evidence for an association between zygosity at six HLA loci and all cancers combined. Increase in number of homozygous at HLA class I loci, class II loci, or class I and II loci was also not associated with cancer overall (Ptrend = 0.28), with adjusted odds ratios (ORs) for risk-per-locus of 1.00 [95% confidence intervals (CIs) = 0.97, 1.03], 1.02 (0.99, 1.04), and 1.01 (0.99, 1.02), respectively. This study does not support a strong role for HLA zygosity on risk of non-virus-associated solid tumors.
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影响因子：
7.3
作者：
Efremova M;Finotello F;Rieder D;Trajanoski Z
通讯作者：
Trajanoski Z
影响因子：
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作者：
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O'Brien, SJ
影响因子：
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作者：
Liu, Zhiwei;Huang, Chih-Jen;Yang, Hwai-, I
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Yang, Hwai-, I
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Hacohen N
影响因子：
11.2
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Wang SS;Carrington M;Berndt SI;Slager SL;Bracci PM;Voutsinas J;Cerhan JR;Smedby KE;Hjalgrim H;Vijai J;Morton LM;Vermeulen R;Paltiel O;Vajdic CM;Linet MS;Nieters A;de Sanjose S;Cozen W;Brown EE;Turner J;Spinelli JJ;Zheng T;Birmann BM;Flowers CR;Becker N;Holly EA;Kane E;Weisenburger D;Maynadie M;Cocco P;Albanes D;Weinstein SJ;Teras LR;Diver WR;Lax SJ;Travis RC;Kaaks R;Riboli E;Benavente Y;Brennan P;McKay J;Delfau-Larue MH;Link BK;Magnani C;Ennas MG;Latte G;Feldman AL;Doo NW;Giles GG;Southey MC;Milne RL;Offit K;Musinsky J;Arslan AA;Purdue MP;Adami HO;Melbye M;Glimelius B;Conde L;Camp NJ;Glenn M;Curtin K;Clavel J;Monnereau A;Cox DG;Ghesquières H;Salles G;Bofetta P;Foretova L;Staines A;Davis S;Severson RK;Lan Q;Brooks-Wilson A;Smith MT;Roman E;Kricker A;Zhang Y;Kraft P;Chanock SJ;Rothman N;Hartge P;Skibola CF
通讯作者：
Skibola CF