Immune measures in alcohol-dependent persons with minor health abnormalities.
Immune measures in alcohol-dependent persons with minor health abnormalities.
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患有轻微健康异常的酒精依赖者的免疫措施。
DOI：
10.1016/s0741-8329(01)00194-x
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Dhaibar,Yesh
中科院分区：
文献类型：
--
作者：
Schleifer,StevenJ;Benton,Tonya;Keller,StevenE;Dhaibar,Yesh
免疫力改变通常与酗酒有关。然而，很少有研究将酒精中毒本身与酒精中毒的医疗后遗症或合并症对免疫系统的影响进行对比。之前，当我们将健康的城市酒精依赖者与社区对照受试者进行比较时，我们发现淋巴细胞亚群、丝裂原反应、粒细胞吞噬作用或自然杀伤细胞活性几乎没有差异。为了开始探索医疗因素的作用，我们将来自同一临床人群但表现出轻度医疗异常 (AMMA)（主要是肝功能测试结果异常）的 11 名酒精依赖者与之前描述的 44 名没有医疗功能障碍的酒精依赖者和 34 名不酗酒的社区人士进行了比较。与非滥用者的研究结果相比，AMMA 的 CD45RA + 诱导剂 - 抑制子/初始细胞 (P < .02) 和 HLA-DR+ 激活 T 细胞 (P < .04) 数量较低，循环 CD56 + 自然杀伤细胞百分比较高 (P < .03)。对伴刀豆球蛋白 A、植物血凝素和商陆有丝分裂原的有丝分裂原反应；自然杀伤细胞活性；粒细胞功能在各组之间没有差异。 AMMA 报告的饮酒量高于其他组。研究结果似乎表明，轻微的医疗状况或与肝功能测试结果异常相关的状况与酒精依赖者报告的一些免疫改变有关。即使在长期酒精依赖者中，免疫变化也可能沿着与总酒精暴露和并发生理异常相关的连续过程发生。临床研究在调查酒精与免疫关系时可能需要控制这种轻微的异常，并且临床干预对于表现出健康受损早期迹象的酒精依赖者可能尤其重要。
Altered immunity is commonly associated with alcoholism. However, few studies have contrasted alcoholism per se with effects of the medical sequelae or comorbidities of alcoholism on the immune system. We previously found few differences in lymphocyte subsets, mitogen response, granulocytic phagocytosis, or natural killer cell activity when we compared healthy urban alcohol-dependent individuals with community control subjects. To begin to explore the role of medical factors, 11 alcohol-dependent persons derived from the same clinical population but showing mild medical abnormalities (AMMAs), primarily abnormal liver function test results, were compared with the previously described 44 alcohol-dependent persons without medical dysfunctions and 34 nonabusing community persons. The AMMAs had lower numbers of CD45RA + inducer–suppressor/naive cells (P < .02) and HLA-DR+-activated T cells (P< .04) compared with findings for nonabusers and higher percentages of circulating CD56 + natural killer cells (P <.03). Mitogen responses to concanavalin A, phytohemagglutinin, and pokeweed mitogen; natural killer cell activity; and granulocyte functions did not differ across groups. The AMMAs reported higher alcohol consumption than that reported by the other groups. The findings seem to indicate that mild medical conditions, or conditions linked to abnormal liver function test results, are associated with some of the immune alterations reported in alcohol-dependent persons. Immune changes, even among chronically alcohol-dependent persons, may occur along a continuum associated with total alcohol exposure and intercurrent physiologic abnormalities. Clinical studies may need to control for such mild abnormalities when investigating alcohol-immune relationships, and clinical interventions may be especially important for alcohol-dependent individuals who show early signs of compromised health.
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简化全血和分离淋巴细胞刺激技术的比较。
DOI：
10.3109/08820138109050707
发表时间：
1981
期刊：
Immunological communications
影响因子：
--
作者：
S. Keller;S. Schleifer;J. Sherman;M. Camerino;H. Smith;M. Stein
通讯作者：
M. Stein
酗酒时的免疫功能：一项对照研究。
DOI：
10.1111/j.1530-0277.1993.tb00763.x
发表时间：
1993
期刊：
Alcoholism, clinical and experimental research
影响因子：
--
作者：
Kronfol,Z;Nair,M;Hill,E;Kroll,P;Brower,K;Greden,J
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DOI：
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发表时间：
1999
期刊：
Alcoholism, clinical and experimental research.
影响因子：
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作者：
Schleifer,SJ;Keller,SE;Shiflett,S;Benton,T;Eckholdt,H
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Eckholdt,H
DOI：
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发表时间：
1991
期刊：
Recent developments in alcoholism : an official publication of the American Medical Society on Alcoholism, the Research Society on Alcoholism, and the National Council on Alcoholism
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作者：
Arria,AM;Tarter,RE;VanThiel,DH
通讯作者：
VanThiel,DH
DOI：
--
发表时间：
1997
期刊：
Alcoholism, clinical and experimental research.
影响因子：
--
作者：
Cook,RT;Li,F;Vandersteen,D;Ballas,ZK;Cook,BL;LaBrecque,DR
通讯作者：
LaBrecque,DR