Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice.
Disrupted social memory ensembles in the ventral hippocampus underlie social amnesia in autism-associated Shank3 mutant mice.
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DOI：
10.1038/s41380-021-01430-5
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发表时间：
2022-04
影响因子：
11
通讯作者：
Okuyama, Teruhiro
中科院分区：
文献类型：
--
作者：
Tao, Kentaro;Chung, Myung;Watarai, Akiyuki;Huang, Ziyan;Wang, Mu-Yun;Okuyama, Teruhiro
记忆同种的能力对于适应性认知功能和社会沟通至关重要，这种能力的损害是自闭症谱系障碍（ASD）的标志。虽然海马腹侧CA 1（vCA 1）神经元已知存储社会记忆，但它们的活动如何协调仍不清楚。在这里，我们表明，vCA 1社会记忆神经元，其特征是增强活动，以响应记忆的个人，优先在锐波波纹（SPW-Rs）重新激活。这些社会重放的尖峰序列反映了在社会经验的theta周期内的神经元活动的时间顺序。在ASD模型Shank 3基因敲除小鼠中，社会记忆神经元的比例减少，SPW-Rs期间的神经元整体锋电位序列被破坏，这与受损的歧视性社会行为相关。这些结果表明，SPW-R介导的神经元系综的顺序再激活是一个典型的机制，用于协调视皮层依赖的社会记忆和其中断的基础与ASD相关的社会记忆缺陷的病理生理。
The ability to remember conspecifics is critical for adaptive cognitive functioning and social communication, and impairments of this ability are hallmarks of autism spectrum disorders (ASDs). Although hippocampal ventral CA1 (vCA1) neurons are known to store social memories, how their activities are coordinated remains unclear. Here we show that vCA1 social memory neurons, characterized by enhanced activity in response to memorized individuals, were preferentially reactivated during sharp-wave ripples (SPW-Rs). Spike sequences of these social replays reflected the temporal orders of neuronal activities within theta cycles during social experiences. In ASD model Shank3 knockout mice, the proportion of social memory neurons was reduced, and neuronal ensemble spike sequences during SPW-Rs were disrupted, which correlated with impaired discriminatory social behavior. These results suggest that SPW-R-mediated sequential reactivation of neuronal ensembles is a canonical mechanism for coordinating hippocampus-dependent social memories and its disruption underlie the pathophysiology of social memory defects associated with ASD.
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影响因子：
30.8
作者：
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通讯作者：
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影响因子：
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25
作者：
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影响因子：
16.2
作者：
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