Tryptophan hydroxylase gene and major psychoses
Tryptophan hydroxylase gene and major psychoses
复制标题
色氨酸羟化酶基因与主要精神病
DOI：
10.1016/s0165-1781(01)00269-4
复制
发表时间：
2001
影响因子：
11.3
通讯作者：
E. Smeraldi
中科院分区：
文献类型：
--
作者：
A. Serretti;R. Lilli;C. Lorenzi;E. Lattuada;C. Cusin;E. Smeraldi
多巴胺能神经递质系统的紊乱与情绪障碍的发病机制有关。色氨酸羟化酶（TPH）基因，编码5-羟色胺生物合成的限速酶，最近有报道与双相情感障碍有关。在这项研究中，我们调查了TPH A218 C基因变异的样本受严重精神病。1424例住院患者受双相情感障碍（n=627），重性抑郁症（n=511），精神分裂症（n=210），妄想（n=48）障碍和精神病性精神障碍（n=27）未另行说明（DSM-IV）;所有患者和380名对照组进行分型的TPH变异使用PCR技术。963例患者的子样本进行了评估，使用精神疾病的操作标准（OPCRIT）。TPH变异与重性精神病无关，但在双相情感障碍中观察到TPH*A/A过量的趋势。精神病学因素的分析也没有显示出任何显着差异;然而，与TPH*C受试者相比，观察到TPH*A基因型男性的抑郁症状较轻的趋势。可能的分层因素，如目前的年龄和发病年龄不影响观察结果。因此，TPH A218 C变异不是本样本中主要精神病症状的主要责任因素。含有TPH*A的变异体可能是患有情绪障碍的男性受试者中抑郁症状或以主要躁狂形式的抑郁症为特征的情绪障碍亚型的保护因素。
Disturbances of the serotoninergic neurotransmitter system have been implicated in the pathogenesis of mood disorders. The tryptophan hydroxylase (TPH) gene, which codes for the rate-limiting enzyme of serotonin biosynthesis, has been recently reported to be associated with bipolar disorder. In this study, we investigated TPH A218C gene variants in a sample of subjects affected by major psychoses. One thousand four hundred and twenty-four inpatients affected by bipolar (n=627), major depressive (n=511), schizophrenic (n=210), delusional (n=48) disorder and psychotic disorder not otherwise specified (n=27) (DSM-IV) were included; all patients and 380 controls were typed for the TPH variants using PCR techniques. A sub-sample of 963 patients was assessed using the Operational Criteria for Psychotic Illness (OPCRIT). TPH variants were not associated with major psychoses, but a trend was observed toward an excess of TPH*A/A in bipolar disorder. The analysis of symptomatology factors did not show any significant difference either; however, a trend was observed for males with the TPH*A genotype to have lower depressive symptoms compared with TPH*C subjects. Possible stratification factors such as current age and age of onset did not affect the observed results. TPH A218C variants are not, therefore, a major liability factor for the symptoms of major psychoses to have in the present sample. TPH*A containing variants may be a protective factor for depressive symptoms among male subjects with mood disorders or for a subtype of mood disorders characterized by a mainly manic form of symptomatology.
色氨酸羟化酶基因的多态性可能与抑郁症患者的自杀行为有关。
DOI：
10.1176/ajp.154.10.1451
发表时间：
1997
期刊：
The American journal of psychiatry.
影响因子：
--
作者：
Mann,JJ;Malone,KM;Nielsen,DA;Goldman,D;Erdos,J;Gelernter,J
通讯作者：
Gelernter,J
终生精神病诊断的最佳估计：方法学研究。
影响因子：
--
作者：
Leckman,JF;Sholomskas,D;Thompson,WD;Belanger,A;Weissman,MM
通讯作者：
Weissman,MM