T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus.
T follicular helper cells and regulatory B cells dynamics in systemic lupus erythematosus.
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系统性红斑狼疮中滤泡辅助 T 细胞和调节性 B 细胞动态
DOI：
10.1371/journal.pone.0088441
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zou H
中科院分区：
文献类型：
--
作者：
Yang X;Yang J;Chu Y;Xue Y;Xuan D;Zheng S;Zou H
滤泡辅助性T（Tfh）细胞辅助效应B细胞，并增强自身免疫，而Tfh细胞在系统性红斑狼疮（SLE）中对调节性B（布雷格）细胞的作用尚不清楚。本研究的目的是探讨布雷格细胞在系统性红斑狼疮（SLE）中所占的比例，以及Tfh细胞对布雷格细胞的作用。首先，我们证实了布雷格细胞在SLE外周血单个核细胞和受累皮肤中的存在。SLE患者外周血布雷格细胞百分比和产生白细胞介素-10（IL-10）的能力均升高。布雷格细胞的百分比在SLE发作期间增加，并在疾病缓解后减少。第二，Tfh细胞扩增不仅与自身抗体的产生有关，而且与布雷格细胞百分比的增加相关。第三，体外研究表明，Tfh细胞来源的IL-21可以促进IL-10的产生和布雷格细胞的分化。总之，这些数据意味着SLE发作可能与Tfh细胞的扩增有关，并且布雷格细胞以调节反馈的方式增加。因此，SLE的发展可能与Tfh细胞和不同B细胞亚群的复杂调节有关。
T follicular helper (Tfh) cells aid effector B cells, and augment autoimmunity, whereas the role of Tfh cells on regulatory B (Breg) cells in systemic lupus erythematosus (SLE) is not known. The aim of this study is to investigate the percentage of Breg cells in SLE, and the role of Tfh cells on Breg cells. First, we demonstrated the presence of Breg cells in SLE peripheral blood mononuclear cells and in involved skins. Both the percentage of circulating Breg cells and the ability to produce interleukin-10 (IL-10) were elevated in SLE patients. The percentage of Breg cells increased during SLE flares and decreased following disease remission. Second, Tfh cell expansion was not only related to autoantibody production but also correlated with the increased percentage of Breg cells. Third, in vitro studies revealed that Tfh cell-derived IL-21 could promote IL-10 production and Breg cell differentiation. In conclusions, these data imply that SLE flares may be linked to the expansion of Tfh cells and that Breg cells are increased in a regulatory feedback manner. Thus, SLE development may be associated with the complex regulation of Tfh cells and diverse B cell subsets.
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影响因子：
32.4
作者：
Herlands, Robin A.;Christensen, Sean R.;Sweet, Rebecca A.;Hershberg, Uri;Shlomchik, Mark J.
通讯作者：
Shlomchik, Mark J.
DOI：
10.4049/jimmunol.0803052
发表时间：
2009-03-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Blair PA;Chavez-Rueda KA;Evans JG;Shlomchik MJ;Eddaoudi A;Isenberg DA;Ehrenstein MR;Mauri C
通讯作者：
Mauri C
影响因子：
32.4
作者：
Nurieva, Roza I.;Chung, Yeonseok;Hwang, Daehee;Yang, Xuexian O.;Kang, Hong Soon;Ma, Li;Wang, Yi-Hong;Watowich, Stephanie S.;Jetten, Anton M.;Tian, Qiang;Dong, Chen
通讯作者：
Dong, Chen
影响因子：
3.7
作者：
van der Vlugt LE;Labuda LA;Ozir-Fazalalikhan A;Lievers E;Gloudemans AK;Liu KY;Barr TA;Sparwasser T;Boon L;Ngoa UA;Feugap EN;Adegnika AA;Kremsner PG;Gray D;Yazdanbakhsh M;Smits HH
通讯作者：
Smits HH
影响因子：
15.9
作者：
Matsushita, Takashi;Yanaba, Koichi;Tedder, Thomas F.
通讯作者：
Tedder, Thomas F.