Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder.
Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder.
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伴有或不伴有快速动眼睡眠行为障碍的帕金森病的临床特征
DOI：
10.1186/s40035-017-0105-5
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发表时间：
2017
影响因子：
12.6
通讯作者：
Wu YC
中科院分区：
文献类型：
--
作者：
Liu Y;Zhu XY;Zhang XJ;Kuo SH;Ondo WG;Wu YC
快速眼动睡眠行为障碍（RBD）和帕金森病（PD）是两种不同的临床疾病，但它们有一些共同的病理和解剖特征。本研究旨在确认中国PD患者中RBD的临床特征。150例PD患者于2013年1月至2014年8月在上海市人民医院神经内科帕金森病和运动障碍中心入组。本研究通过REM睡眠行为障碍筛查问卷（RBDSQ）检查了有或无RBD的PD患者，在“开”状态下通过统一PD评定量表（Unified PD Rating Scale，UFRS）III评估运动亚型，并比较了代表震颤、僵硬、不对称和轴性的子量表评分。研究人员还评估了汉密尔顿焦虑量表（HAMA）、汉密尔顿抑郁量表（HAMD）、简易精神状态检查量表（MMSE）、临床痴呆评定量表（CDR）和帕金森病睡眠量表（PDSS）。141例PD患者进入最终研究。30例（21.28%）PD患者诊断为可能的RBD（pRBD），RBDSQ评分≥ 6分。pRBD+组和pRBD−组之间的年龄（包括PD发作年龄和PD持续时间）、性别、吸烟状况、饮酒或咖啡使用、嗅觉丧失或冻结的存在、MERS III和H-Y分期无显著差异。pRBD+ PD组MMSE评分低于PD组，PDSS评分高于PD组，且pRBD+ PD组焦虑、抑郁、便秘、幻觉发生率更高，体位性低血压发生率更高。pRBD+ PD患者在非运动症状方面表现出更大的变化。然而，运动缺陷没有增加。
Rapid eye movement sleep behavior disorder (RBD) and Parkinson’s disease (PD) are two distinct clinical diseases but they share some common pathological and anatomical characteristics. This study aims to confirm the clinical features of RBD in Chinese PD patients. One hundred fifty PD patients were enrolled from the Parkinson`s disease and Movement Disorders Center in Department of Neurology, Shanghai General Hospital from January 2013 to August 2014. This study examined PD patients with or without RBD as determined by the REM Sleep Behavior Disorder Screening Questionnaire (RBDSQ), assessed motor subtype by Unified PD Rating Scale (UPDRS) III at “on” state, and compared the sub-scale scores representing tremor, rigidity, appendicular and axial. Investigators also assessed the Hamilton Anxiety Scale (HAMA), Hamilton Depression Scale (HAMD), Mini-Mental State Examination (MMSE), Clinical Dementia Rating (CDR), and Parkinson’s disease Sleep Scale (PDSS). One hundred fourty one PD patients entered the final study. 30 (21.28%) PD patients had probable RBD (pRBD) diagnosed with a RBDSQ score of 6 or above. There were no significant differences for age, including age of PD onset and PD duration, gender, smoking status, alcohol or coffee use, presence of anosmia or freezing, UPDRS III, and H-Y stages between the pRBD+ and pRBD− groups. pRBD+ group had lower MMSE scores, higher PDSS scores, and pRBD+ PD patients had more prominent proportion in anxiety, depression, constipation, hallucination and a greater prevalence of orthostatic hypotension. pRBD+ PD patients exhibited greater changes in non-motor symptoms. However, there was no increase in motor deficits.
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影响因子：
5.6
作者：
Heister, David S.;Hayar, Abdallah;Garcia-Rill, Edgar
通讯作者：
Garcia-Rill, Edgar
影响因子：
5.6
作者：
Delazer, Margarete;Hoegl, Birgit;Frauscher, Birgit
通讯作者：
Frauscher, Birgit
影响因子：
11
作者：
Postuma, R. B.;Gagnon, J. F.;Montplaisir, J.
通讯作者：
Montplaisir, J.
影响因子：
14.5
作者：
Fling, Brett W.;Cohen, Rajal G.;Horak, Fay B.
通讯作者：
Horak, Fay B.
影响因子：
1.9
作者：
Özekmekçi, S;Apaydin, H;Kiliç, E
通讯作者：
Kiliç, E