The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma.
The Role of PI3K/Akt/mTOR Signaling in Gastric Carcinoma.
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DOI：
10.3390/cancers6031441
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发表时间：
2014-07-07
期刊：
影响因子：
5.2
通讯作者：
Yashiro M
中科院分区：
文献类型：
--
作者：
Matsuoka T;Yashiro M
磷脂酰肌醇3-激酶(PI3K)/Akt/哺乳动物雷帕霉素靶蛋白（mTOR）通路是多种受体酪氨酸激酶诱导的关键信号通路之一。越来越多的证据表明，该通路是细胞生长、代谢、存活、转移和化疗耐药的重要促进因子。胃癌中PI3K/Akt/mTOR通路的遗传改变经常被证实。多种分子靶向治疗目前正在进行实体瘤患者的临床试验。然而，除了erbb2靶向抗体外，包括PI3K/Akt/mTOR抑制剂在内的靶向药物尚未被批准用于胃癌患者的治疗。本文就PI3K/Akt/mTOR信号通路在胃癌发病机制中的作用及胃癌可能的治疗靶点进行综述。提高对胃癌中PI3K/Akt/mTOR通路的认识将有助于理解肿瘤发展机制，并确定胃癌抗癌治疗的理想靶点。
The phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway is one of the key signaling pathways induced by various receptor-tyrosine kinases. Accumulating evidence shows that this pathway is an important promoter of cell growth, metabolism, survival, metastasis, and resistance to chemotherapy. Genetic alterations in the PI3K/Akt/mTOR pathway in gastric carcinoma have often been demonstrated. Many kinds of molecular targeting therapies are currently undergoing clinical testing in patients with solid tumors. However, with the exception of the ErbB2-targeting antibody, targeting agents, including PI3K/Akt/mTOR inhibitors, have not been approved for treatment of patients with gastric carcinoma. This review summarizes the current knowledge on PI3K/Akt/mTOR signaling in the pathogenesis of gastric carcinoma and the possible therapeutic targets for gastric carcinoma. Improved knowledge of the PI3K/Akt/mTOR pathway in gastric carcinoma will be useful in understanding the mechanisms of tumor development and for identifying ideal targets of anticancer therapy for gastric carcinoma.
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