The role of genetics in the etiology of schizophrenia.
The role of genetics in the etiology of schizophrenia.
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DOI：
10.1016/j.psc.2009.12.003
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发表时间：
2010-03
影响因子：
1.7
通讯作者：
Duan, Jubao
中科院分区：
文献类型：
--
作者：
Gejman, Pablo V.;Sanders, Alan R.;Duan, Jubao
Genome-wide experiments are rapidly changing our understanding of the molecular genetics of schizophrenia. These studies have discovered uncommon copy number variations (mainly deletions) associated with schizophrenia as well as common SNPs with alleles associated with schizophrenia. The aggregate data provide initial support for polygenic inheritance and for genetic overlap of schizophrenia with autism and with bipolar disorder. It is anticipated that as genetic discoveries accumulate, the application of a myriad of tools from systems biology will lead to a delineation of biological pathways involved in the pathophysiology of schizophrenia, and eventually to new therapies.
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