Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients.
Intradiscal quantitative chemical exchange saturation transfer MRI signal correlates with discogenic pain in human patients.
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DOI：
10.1038/s41598-021-97672-y
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发表时间：
2021-09-28
影响因子：
4.6
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Pelled G;Salas MM;Han P;Gill HE 3rd;Lautenschlager KA;Lai TT;Shawver CM;Hoch MB;Goff BJ;Betts AM;Zhou Z;Lynch C;Schroeder G;Bez M;Maya MM;Bresee C;Gazit Z;McCallin JP 3rd;Gazit D;Li D
腰痛 (LBP) 通常是椎间盘退变过程的结果。椎间盘源性疼痛的确切起源是通过侵入性椎间盘造影（PD）检查来诊断的。此前，我们开发了定量化学交换饱和转移 (qCEST) 磁共振成像 (MRI) 来检测 pH 作为椎间盘源性疼痛的生物标志物。基于这些发现，我们发起了一项临床研究，旨在评估 LBP 患者 qCEST 值与 PD 结果之间的相关性。 25 名患有慢性腰痛的志愿者接受了 T2 加权 (T2w) 和 qCEST MRI 扫描，然后进行 PD。总共分析了 72 个光盘。疼痛椎间盘的平均 qCEST 信号值显着高于非疼痛椎间盘 (p = 0.012)。与无痛椎间盘相比，疼痛椎间盘的 qCEST 和标准化 T2w 之间的比率显着更高 (p = 0.0022)。接受者操作特征 (ROC) 分析表明，qCEST/T2w 比率可用于区分疼痛和非疼痛椎间盘，敏感性为 78%，特异性为 81%。研究结果表明，qCEST 与常用的 T2w 扫描结合可用于诊断椎间盘源性疼痛。
Low back pain (LBP) is often a result of a degenerative process in the intervertebral disc. The precise origin of discogenic pain is diagnosed by the invasive procedure of provocative discography (PD). Previously, we developed quantitative chemical exchange saturation transfer (qCEST) magnetic resonance imaging (MRI) to detect pH as a biomarker for discogenic pain. Based on these findings we initiated a clinical study with the goal to evaluate the correlation between qCEST values and PD results in LBP patients. Twenty five volunteers with chronic low back pain were subjected to T2-weighted (T2w) and qCEST MRI scans followed by PD. A total of 72 discs were analyzed. The average qCEST signal value of painful discs was significantly higher than non-painful discs (p = 0.012). The ratio between qCEST and normalized T2w was found to be significantly higher in painful discs compared to non-painful discs (p = 0.0022). A receiver operating characteristics (ROC) analysis indicated that qCEST/T2w ratio could be used to differentiate between painful and non-painful discs with 78% sensitivity and 81% specificity. The results of the study suggest that qCEST could be used for the diagnosis of discogenic pain, in conjunction with the commonly used T2w scan.
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影响因子：
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作者：
Ito, M;Incorvaia, KM;Rosenbaum, AE
通讯作者：
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