Intracranial Hemorrhage in Patients with Coronavirus Disease 2019 (COVID-19): A Case Series.
Intracranial Hemorrhage in Patients with Coronavirus Disease 2019 (COVID-19): A Case Series.
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DOI：
10.1016/j.wneu.2021.07.067
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发表时间：
2021-10
影响因子：
2
通讯作者：
Jabbour P
中科院分区：
文献类型：
--
作者：
Abbas R;El Naamani K;Sweid A;Schaefer JW;Bekelis K;Sourour N;Elhorany M;Pandey AS;Tjoumakaris S;Gooch MR;Herial NA;Rosenwasser RH;Jabbour P
2019冠状病毒病（COVID-19）大流行是一项持续的公共卫生紧急事件。虽然大多数病例最终都是无症状或轻微疾病，但越来越多的证据表明，一些COVID-19感染会导致非常规的可怕后果。我们试图描述感染严重急性呼吸综合征冠状病毒2（SARS-CoV-2）的颅内出血患者的特征。此外，与现有的文献中，我们提出了一个可能的SARS-CoV-2感染和颅内出血之间的关联的想法，并提出可能的病理生理机制连接两者。我们回顾性收集并分析了来自4个三级脑血管中心的SARS-CoV-2阳性的颅内出血病例。我们共确定了19例患者，包括11例男性（58%）和8例女性（42%）。平均年龄为52.2岁，95%的患者年龄小于75岁。关于COVID-19疾病，50%患有轻度至中度疾病，21%患有重度疾病，20%患有需要插管的危重疾病。在19例病例中，12例患者发生脑实质内出血（63%），6例患者发生蛛网膜下腔出血（32%），1例患者发生硬膜下血肿（5%）。共有43%的患者脑出血评分为0-2分，57%的患者评分为3-6分。23%的放电时修改后的兰金等级核心为0-2，77%的放电时修改后的兰金等级核心为3-6。死亡率为59%。我们的系列揭示了与典型的非COVID-19病例相比，COVID-19阳性病例中脑出血的独特模式，即出血的严重程度，高死亡率和患者的年轻化。进一步的研究是必要的，以描绘SARS-CoV-2感染和颅内出血之间的潜在联系。
The coronavirus disease 2019 (COVID-19) pandemic is an ongoing public health emergency. While most cases end in asymptomatic or minor illness, there is growing evidence that some COVID-19 infections result in nonconventional dire consequences. We sought to describe the characteristics of patients with intracranial hemorrhage who were infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Also, with the existing literature, we raise the idea of a possible association between SARS-CoV-2 infection and intracranial hemorrhage and propose possible pathophysiological mechanisms connecting the two. We retrospectively collected and analyzed intracranial hemorrhage cases who were also positive for SARS-CoV-2 from 4 tertiary-care cerebrovascular centers. We identified a total of 19 patients consisting of 11 males (58%) and 8 females (42%). Mean age was 52.2, with 95% younger than 75 years of age. With respect to COVID-19 illness, 50% had mild-to-moderate disease, 21% had severe disease, and 20% had critical disease requiring intubation. Of the 19 cases, 12 patients had intraparenchymal hemorrhage (63%), 6 had subarachnoid hemorrhage (32%), and 1 patient had a subdural hematoma (5%). A total of 43% had an intracerebral hemorrhage score of 0–2 and 57% a score of 3–6. Modified Rankin Scale cores at discharge were 0–2 in 23% and 3–6 in 77%. The mortality rate was 59%. Our series sheds light on a distinct pattern of intracerebral hemorrhage in COVID-19–positive cases compared with typical non–COVID-19 cases, namely the severity of hemorrhage, high mortality rate, and the young age of patients. Further research is warranted to delineate a potential association between SARS-CoV-2 infection and intracranial hemorrhage.
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DOI：
10.4269/ajtmh.20-0869
发表时间：
2020-11
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Mukherjee A;Ghosh R;Furment MM
通讯作者：
Furment MM
影响因子：
8.2
作者：
An SJ;Kim TJ;Yoon BW
通讯作者：
Yoon BW
DOI：
10.1007/s10072-020-04870-z
发表时间：
2021-01
期刊：
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
影响因子：
--
作者：
Cheruiyot I;Sehmi P;Ominde B;Bundi P;Mislani M;Ngure B;Olabu B;Ogeng'o JA
通讯作者：
Ogeng'o JA
影响因子：
9.9
作者：
Jolink, Wilmar M. T.;Klijn, Catharina J. M.;Vaartjes, Ilonca
通讯作者：
Vaartjes, Ilonca
影响因子：
3.9
作者：
Nawabi, Jawed;Morotti, Andrea;Sporns, Peter
通讯作者：
Sporns, Peter