Human lung hydrolases delineate Mycobacterium tuberculosis-macrophage interactions and the capacity to control infection.
Human lung hydrolases delineate Mycobacterium tuberculosis-macrophage interactions and the capacity to control infection.
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DOI：
10.4049/jimmunol.1100823
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发表时间：
2011-07-01
期刊：
影响因子：
--
通讯作者：
Torrelles JB
中科院分区：
文献类型：
--
作者：
Arcos J;Sasindran SJ;Fujiwara N;Turner J;Schlesinger LS;Torrelles JB
Pulmonary surfactant contains homeostatic and antimicrobial hydrolases. When Mycobacterium tuberculosis is initially deposited in the terminal bronchioles and alveoli, as well as following release from lysed macrophages, bacilli are in intimate contact with these lung surfactant hydrolases. We identified and measured several hydrolases in human alveolar lining fluid and lung tissue that, at their physiological concentrations, dramatically modified the M. tuberculosis cell envelope. Independent of their action time (15 min to 12 h), the effects of the hydrolases on the M. tuberculosis cell envelope resulted in a significant decrease (60–80%) in M. tuberculosis association with, and intracellular growth of the bacteria within, human macrophages. The cell envelope-modifying effects of the hydrolases also led to altered M. tuberculosis intracellular trafficking and induced a protective proin-flammatory response to infection. These findings add a new concept to our understanding of M. tuberculosis–macrophage inter-actions (i.e., the impact of lung surfactant hydrolases on M. tuberculosis infection).
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影响因子：
3.5
作者：
EHLE, H;MULLER, E;HORN, A
通讯作者：
HORN, A
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DOI：
10.1084/jem.20051239
发表时间：
2005-10-03
期刊：
The Journal of experimental medicine
影响因子：
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作者：
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通讯作者：
Schlesinger LS
影响因子：
4.4
作者：
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通讯作者：
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DOI：
10.1111/j.1574-695x.1999.tb01275.x
发表时间：
1999-06-01
影响因子：
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作者：
Fujiwara, N;Pan, JW;Yano, I
通讯作者：
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DOI：
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1985-12-04
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
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作者：
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通讯作者：
VANGOLDE, LMG