Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women.
Cardiometabolic phenotypes and mitochondrial DNA copy number in two cohorts of UK women.
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DOI：
10.1016/j.mito.2017.08.007
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发表时间：
2018-03
期刊：
影响因子：
4.4
通讯作者：
Rodriguez S
中科院分区：
文献类型：
--
作者：
Guyatt AL;Burrows K;Guthrie PAI;Ring S;McArdle W;Day INM;Ascione R;Lawlor DA;Gaunt TR;Rodriguez S
线粒体基因组在个体之间以不同的拷贝数存在。线粒体容易受到氧化应激的影响，其功能障碍可能与心血管疾病有关。在两个独立的欧洲血统女性队列中评估了线粒体 DNA 拷贝数与心脏代谢危险因素（血脂、血糖特征、炎症标志物、人体测量学和血压）的关联，其中一组在平均 (SD) 年龄 30 (4.3) 岁 (N = 2278) 时测量结果，第二组在 69.4 (5.5) 岁 (N = 2872) 时测量结果。通过定量聚合酶链式反应测定线粒体DNA拷贝数。根据吸烟、社会人口状况、实验室因素和白细胞特征对关联进行了调整。在两个队列中评估的总共 12 项结果中，线粒体 DNA 拷贝数与大多数结果几乎没有相关性或没有相关性（点估计值接近于零，几乎所有 p 值都 > 0.01）。最有力的证据是老年队列与胰岛素呈负相关（标准化β[95%CI]：−0.06，[−0.098，−0.022]，p=0.002），但这种关联在年轻队列中并未重复。我们的研究结果并不支持线粒体 DNA 拷贝数的变化对欧洲血统女性的心脏代谢危险因素有重要影响。研究人员对两组女性的线粒体 DNA 拷贝数与心脏代谢特征的关系进行了研究。针对一些可能的混杂因素对关联进行了调整。在较老的队列中，没有足够的证据表明线粒体 DNA 拷贝数与胰岛素之间存在负相关关系。研究结果并未表明 mtDNA 拷贝数与大多数研究表型之间存在重要关联。
The mitochondrial genome is present at variable copy number between individuals. Mitochondria are vulnerable to oxidative stress, and their dysfunction may be associated with cardiovascular disease. The association of mitochondrial DNA copy number with cardiometabolic risk factors (lipids, glycaemic traits, inflammatory markers, anthropometry and blood pressure) was assessed in two independent cohorts of European origin women, one in whom outcomes were measured at mean (SD) age 30 (4.3) years (N = 2278) and the second at 69.4 (5.5) years (N = 2872). Mitochondrial DNA copy number was assayed by quantitative polymerase chain reaction. Associations were adjusted for smoking, sociodemographic status, laboratory factors and white cell traits. Out of a total of 12 outcomes assessed in both cohorts, mitochondrial DNA copy number showed little or no association with the majority (point estimates were close to zero and nearly all p-values were > 0.01). The strongest evidence was for an inverse association in the older cohort with insulin (standardised beta [95%CI]: − 0.06, [− 0.098, − 0.022], p = 0.002), but this association did not replicate in the younger cohort. Our findings do not provide support for variation in mitochondrial DNA copy number having an important impact on cardio-metabolic risk factors in European origin women. MtDNA copy number was studied in relation to cardiometabolic traits in two cohorts of women. Associations were adjusted for a number of possible confounders. There was weak evidence for an inverse relationship between mtDNA copy number and insulin in the older cohort. The findings do not suggest an important association between mtDNA copy number and the majority of phenotypes studied.
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影响因子：
4.5
作者：
Ding J;Sidore C;Butler TJ;Wing MK;Qian Y;Meirelles O;Busonero F;Tsoi LC;Maschio A;Angius A;Kang HM;Nagaraja R;Cucca F;Abecasis GR;Schlessinger D
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DOI：
10.1016/j.mrfmmm.2004.10.003
发表时间：
2005-02-15
影响因子：
2.3
作者：
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通讯作者：
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线粒体 DNA 水平与虚弱和全因死亡率的关联。
影响因子：
4.7
作者：
Ashar, Foram N.;Moes, Anna;Moore, Ann Z.;Grove, Megan L.;Chaves, Paulo H. M.;Coresh, Josef;Newman, Anne B.;Matteini, Amy M.;Bandeen-Roche, Karen;Boerwinkle, Eric;Walston, Jeremy D.;Arking, Dan E.
通讯作者：
Arking, Dan E.