Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.
Defining the momiome: Promiscuous information transfer by mobile mitochondria and the mitochondrial genome.
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DOI：
10.1016/j.semcancer.2017.05.004
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发表时间：
2017-12
影响因子：
14.5
通讯作者：
Singh KK
中科院分区：
文献类型：
--
作者：
Singh B;Modica-Napolitano JS;Singh KK
线粒体是一种复杂的胞内细胞器，由于其在氧化代谢中起着核心作用，长期以来一直被认为是真核细胞的动力源。在过去的十年中，对线粒体研究的兴趣的复苏表明，线粒体在细胞信号传导、增殖、细胞代谢和细胞死亡中也起着关键作用，线粒体的遗传和/或代谢改变导致了包括癌症在内的许多疾病。线粒体已被确定为信号细胞器，能够介导双向细胞内信息传递：顺行（从细胞核到线粒体）和逆行（从线粒体到细胞核）。最近，越来越多的证据表明，线粒体的作用也延伸到细胞间的通讯中，线粒体基因组（mtDNA）甚至整个线粒体确实是可移动的，可以介导细胞间的信息传递。我们将线粒体和线粒体dna的这种混杂信息传递功能定义为“染色体组”，包括线粒体和线粒体基因组的所有移动功能。在此，我们回顾“染色体组”并探讨其在癌症发生、进展和治疗中的作用。
Mitochondria are complex intracellular organelles that have long been identified as the powerhouses of eukaryotic cells because of the central role they play in oxidative metabolism. A resurgence of interest in the study of mitochondria during the past decade has revealed that mitochondria also play key roles in cell signaling, proliferation, cell metabolism and cell death, and that genetic and/or metabolic alterations in mitochondria contribute to a number of diseases, including cancer. Mitochondria have been identified as signaling organelles, capable of mediating bidirectional intracellular information transfer: anterograde (from nucleus to mitochondria) and retrograde (from mitochondria to nucleus). More recently, evidence is now building that the role of mitochondria extends to intercellular communication as well, and that the mitochondrial genome (mtDNA) and even whole mitochondria are indeed mobile and can mediate information transfer between cells. We define this promiscuous information transfer function of mitochondria and mtDNA as “momiome” to include all mobile functions of mitochondria and the mitochondrial genome. Herein we review the “momiome” and explore its role in cancer development, progression, and treatment.
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影响因子：
11.2
作者：
Akalay, Intissar;Janji, Bassam;Chouaib, Salem
通讯作者：
Chouaib, Salem
DOI：
10.1523/jneurosci.3338-08.2008
发表时间：
2008-11-19
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Aschrafi A;Schwechter AD;Mameza MG;Natera-Naranjo O;Gioio AE;Kaplan BB
通讯作者：
Kaplan BB
DOI：
10.1093/dnares/dst029
发表时间：
2013-12
期刊：
DNA research : an international journal for rapid publication of reports on genes and genomes
影响因子：
--
作者：
Bellizzi D;D'Aquila P;Scafone T;Giordano M;Riso V;Riccio A;Passarino G
通讯作者：
Passarino G
影响因子：
12.4
作者：
Biswas, G;Anandatheerthavarada, HK;Avadhani, NG
通讯作者：
Avadhani, NG
影响因子：
4
作者：
Berridge, Michael V.;McConnell, Melanie J.;Neuzil, Jiri
通讯作者：
Neuzil, Jiri