Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.
Molecular and cellular mechanisms of aging in hematopoietic stem cells and their niches.
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DOI：
10.1186/s13045-020-00994-z
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发表时间：
2020-11-23
影响因子：
28.5
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Zhang L;Mack R;Breslin P;Zhang J
衰老导致遗传和表观遗传变化，导致造血干细胞(HSC)功能下降。这种变化会导致与衰老相关的造血/免疫损伤和造血紊乱。了解这些变化是如何启动的，以及它们是如何进展的，将有助于开发能够改善老年人生活质量的药物，并治疗并可能预防与衰老有关的造血疾病。在这里，我们回顾了HSC老化研究的最新进展，并讨论了HSC内在事件以及那些与老化的骨髓微环境有关的事件在HSC老化的整个过程中的作用。此外，我们还讨论了调节HSC衰老的可能机制。
Aging drives the genetic and epigenetic changes that result in a decline in hematopoietic stem cell (HSC) functioning. Such changes lead to aging-related hematopoietic/immune impairments and hematopoietic disorders. Understanding how such changes are initiated and how they progress will help in the development of medications that could improve the quality life for the elderly and to treat and possibly prevent aging-related hematopoietic diseases. Here, we review the most recent advances in research into HSC aging and discuss the role of HSC-intrinsic events, as well as those that relate to the aging bone marrow niche microenvironment in the overall processes of HSC aging. In addition, we discuss the potential mechanisms by which HSC aging is regulated.
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8.8
作者：
Brown K;Xie S;Qiu X;Mohrin M;Shin J;Liu Y;Zhang D;Scadden DT;Chen D
通讯作者：
Chen D
影响因子：
64.5
作者：
Bernitz, Jeffrey M.;Kim, Huen Suk;MacArthur, Ben;Sieburg, Hans;Moore, Kateri
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Moore, Kateri
影响因子：
64.5
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Scadden, David T.
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Asada N;Kunisaki Y;Pierce H;Wang Z;Fernandez NF;Birbrair A;Ma'ayan A;Frenette PS
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Frenette PS
影响因子：
64.8
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Busch, Katrin;Klapproth, Kay;Rodewald, Hans-Reimer
通讯作者：
Rodewald, Hans-Reimer