Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.
Education in Twins and Their Parents Across Birth Cohorts Over 100 years: An Individual-Level Pooled Analysis of 42-Twin Cohorts.
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DOI：
10.1017/thg.2017.49
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发表时间：
2017-10
期刊：
影响因子：
--
通讯作者：
Kaprio J
中科院分区：
文献类型：
--
作者：
Silventoinen K;Jelenkovic A;Latvala A;Sund R;Yokoyama Y;Ullemar V;Almqvist C;Derom CA;Vlietinck RF;Loos RJF;Kandler C;Honda C;Inui F;Iwatani Y;Watanabe M;Rebato E;Stazi MA;Fagnani C;Brescianini S;Hur YM;Jeong HU;Cutler TL;Hopper JL;Busjahn A;Saudino KJ;Ji F;Ning F;Pang Z;Rose RJ;Koskenvuo M;Heikkilä K;Cozen W;Hwang AE;Mack TM;Siribaddana SH;Hotopf M;Sumathipala A;Rijsdijk F;Sung J;Kim J;Lee J;Lee S;Nelson TL;Whitfield KE;Tan Q;Zhang D;Llewellyn CH;Fisher A;Burt SA;Klump KL;Knafo-Noam A;Mankuta D;Abramson L;Medland SE;Martin NG;Montgomery GW;Magnusson PKE;Pedersen NL;Dahl Aslan AK;Corley RP;Huibregtse BM;Öncel SY;Aliev F;Krueger RF;McGue M;Pahlen S;Willemsen G;Bartels M;van Beijsterveldt CEM;Silberg JL;Eaves LJ;Maes HH;Harris JR;Brandt I;Nilsen TS;Rasmussen F;Tynelius P;Baker LA;Tuvblad C;Ordoñana JR;Sánchez-Romera JF;Colodro-Conde L;Gatz M;Butler DA;Lichtenstein P;Goldberg JH;Harden KP;Tucker-Drob EM;Duncan GE;Buchwald D;Tarnoki AD;Tarnoki DL;Franz CE;Kremen WS;Lyons MJ;Maia JA;Freitas DL;Turkheimer E;Sørensen TIA;Boomsma DI;Kaprio J
单卵双胞胎（MZ）和异卵双胞胎（DZ）在各种表型上是否不同，对于双胞胎的遗传建模和从双胞胎研究中得出的推断非常重要。我们在一个大型汇总数据集中分析了MZ和DZ双胞胎在个体、母亲和父亲教育方面是否存在差异。收集了来自27对双胞胎队列（53%的女性，39%的MZ双胞胎）的218,362对成年双胞胎的个人教育信息，以及来自28对双胞胎队列（52%的女性，38%的MZ双胞胎）的147,315对和143,056对双胞胎的母亲和父亲教育信息。我们收集了来自19个国家的42对双胞胎的个人或父母教育信息。将原始的教育分类转换为教育年限，并使用线性回归模型进行分析。总体而言，MZ男性比DZ双胞胎受教育时间长0.26 （95% CI[0.21, 0.31]）年，MZ女性比DZ双胞胎受教育时间长0.17 （95% CI[0.12, 0.21]）年。在最近的出生队列中，男性和女性的合子性差异都变小了。出生在1990-1999年（0.16年，95% CI[0.08, 0.25]）和2000年及以后（0.11年，95% CI[0.00, 0.22]）的DZ双胞胎的父亲与MZ双胞胎的父亲相比，父母的受教育时间稍长。结果表明，MZ和DZ双胞胎的个人教育年限和父母教育年限基本相似。我们认为，MZ和DZ双胞胎之间的社会经济差异是如此之小，以至于基于双胞胎数据的遗传建模的推断不受影响。
Whether monozygotic (MZ) and dizygotic (DZ) twins differ from each other in a variety of phenotypes is important for genetic twin modeling and for inferences made from twin studies in general. We analyzed whether there were differences in individual, maternal and paternal education between MZ and DZ twins in a large pooled dataset. Information was gathered on individual education for 218,362 adult twins from 27 twin cohorts (53% females; 39% MZ twins), and on maternal and paternal education for 147,315 and 143,056 twins respectively, from 28 twin cohorts (52% females; 38% MZ twins). Together, we had information on individual or parental education from 42 twin cohorts representing 19 countries. The original education classifications were transformed to education years and analyzed using linear regression models. Overall, MZ males had 0.26 (95% CI [0.21, 0.31]) years and MZ females 0.17 (95% CI [0.12, 0.21]) years longer education than DZ twins. The zygosity difference became smaller in more recent birth cohorts for both males and females. Parental education was somewhat longer for fathers of DZ twins in cohorts born in 1990–1999 (0.16 years, 95% CI [0.08, 0.25]) and 2000 or later (0.11 years, 95% CI [0.00, 0.22]), compared with fathers of MZ twins. The results show that the years of both individual and parental education are largely similar in MZ and DZ twins. We suggest that the socio-economic differences between MZ and DZ twins are so small that inferences based upon genetic modeling of twin data are not affected.
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DOI：
10.1017/thg.2015.57
发表时间：
2015-10
期刊：
Twin research and human genetics : the official journal of the International Society for Twin Studies
影响因子：
--
作者：
Jelenkovic A;Yokoyama Y;Sund R;Honda C;Bogl LH;Aaltonen S;Ji F;Ning F;Pang Z;Ordoñana JR;Sánchez-Romera JF;Colodro-Conde L;Burt SA;Klump KL;Medland SE;Montgomery GW;Kandler C;McAdams TA;Eley TC;Gregory AM;Saudino KJ;Dubois L;Boivin M;Tarnoki AD;Tarnoki DL;Haworth CM;Plomin R;Öncel SY;Aliev F;Stazi MA;Fagnani C;D'Ippolito C;Craig JM;Saffery R;Siribaddana SH;Hotopf M;Sumathipala A;Rijsdijk F;Spector T;Mangino M;Lachance G;Gatz M;Butler DA;Bayasgalan G;Narandalai D;Freitas DL;Maia JA;Harden KP;Tucker-Drob EM;Kim B;Chong Y;Hong C;Shin HJ;Christensen K;Skytthe A;Kyvik KO;Derom CA;Vlietinck RF;Loos RJ;Cozen W;Hwang AE;Mack TM;He M;Ding X;Chang B;Silberg JL;Eaves LJ;Maes HH;Cutler TL;Hopper JL;Aujard K;Magnusson PK;Pedersen NL;Aslan AK;Song YM;Yang S;Lee K;Baker LA;Tuvblad C;Bjerregaard-Andersen M;Beck-Nielsen H;Sodemann M;Heikkilä K;Tan Q;Zhang D;Swan GE;Krasnow R;Jang KL;Knafo-Noam A;Mankuta D;Abramson L;Lichtenstein P;Krueger RF;McGue M;Pahlen S;Tynelius P;Duncan GE;Buchwald D;Corley RP;Huibregtse BM;Nelson TL;Whitfield KE;Franz CE;Kremen WS;Lyons MJ;Ooki S;Brandt I;Nilsen TS;Inui F;Watanabe M;Bartels M;van Beijsterveldt TC;Wardle J;Llewellyn CH;Fisher A;Rebato E;Martin NG;Iwatani Y;Hayakawa K;Sung J;Harris JR;Willemsen G;Busjahn A;Goldberg JH;Rasmussen F;Hur YM;Boomsma DI;Sørensen TI;Kaprio J;Silventoinen K
通讯作者：
Silventoinen K
影响因子：
7.2
作者：
Laaksonen, Mikko;Aittomaki, Akseli;Lahelma, Eero
通讯作者：
Lahelma, Eero
影响因子：
2.8
作者：
Penninkilampi-Kerola, V;Moilanen, I;Kaprio, J
通讯作者：
Kaprio, J
影响因子：
3.8
作者：
Hjern, Anders;Ekeus, Cecilia;Lindblad, Frank
通讯作者：
Lindblad, Frank
影响因子：
5
作者：
Myrskylae, Mikko;Silventoinen, Karri;Rasmussen, Finn
通讯作者：
Rasmussen, Finn