Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production.
Normative variation in self-reported sleep quality and sleep debt is associated with stimulated pro-inflammatory cytokine production.
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DOI：
10.1016/j.biopsycho.2009.04.008
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发表时间：
2009-09
影响因子：
2.6
通讯作者：
Manuck, Stephen B.
中科院分区：
文献类型：
--
作者：
Prather, Aric A.;Marsland, Anna L.;Hall, Martica;Neumann, Serina A.;Muldoon, Matthew F.;Manuck, Stephen B.
先天性炎症通路的激活，标志着促炎细胞因子的产生增加，已被提出作为一个潜在的机制联系睡眠不良和炎症性疾病的风险。在本研究中，我们在156名健康成年人的社区样本中检查了自我报告的睡眠质量和持续时间的相关性，以及计算的睡眠负债与促炎细胞因子白细胞介素（IL）-6，IL-1β和肿瘤坏死因子（TNF）-α的产生的相关性。双变量相关性揭示了睡眠质量与所有三种促炎细胞因子的产生之间的负相关性，在控制人口统计学和健康特征后，IL-1β保留了这三种促炎细胞因子。分层线性回归还显示，在调整协变量后，较高的睡眠债评分预测IL-1β和IL-6的产生更大。二次分析显示，在预测IL-1β时，睡眠债和体重指数（BMI）之间存在相互作用，这表明睡眠债对细胞因子产生的影响在BMI评分较低的参与者中更大。进一步探索这种潜在的心理生理途径连接睡眠困难和炎症性疾病的易感性是必要的。
Activation of innate inflammatory pathways, marked by increased production of pro-inflammatory cytokines, has been proposed as a potential mechanism linking poor sleep and inflammatory disease risk. In the present study, we examined associations of self-reported sleep quality and duration, and a calculated measure of sleep debt with the production of pro-inflammatory cytokines, interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α among a community sample of 156 healthy adults. Bivariate correlations revealed an inverse association between sleep quality and production of all three pro-inflammatory cytokines that was retained for IL-1β after controlling for demographic and health characteristics. Hierarchical linear regressions also revealed that higher sleep debt scores predicted greater production of IL-1β and IL-6 after adjusting for covariates. Secondary analyses showed an interaction between sleep debt and body mass index (BMI) in the prediction IL-1β, suggesting that the impact of sleep debt on cytokine production is greater among participants with lower BMI scores. Further exploration of this potential psychophysiological pathway linking sleep difficulty and inflammatory disease susceptibility is warranted.
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影响因子：
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